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Mechanisms regulating neural progenitor expansion in the developing brain

Description: Project Narrative Autosomal recessive primary microcephaly (MCPH) is a congenital brain disorder. MCPH patients exhibit small brain sizes and are associated with varying degrees of intellectual disability. However, the disease mechanisms of MCPH still remain obscure. This project seeks to establish a novel mechanism of MCPH by understanding how dysregulation of mitotic progression and cell cycle re-entry leads to neural progenitor cell (NPC) reduction in MPCH.
Funding type: research
Funder scheme: R01
Start date: 2016-09-01
End date: 2023-08-31
Investigator: JIANFU CHEN (lead)
Subfield: Cell Biology
Funded outputs count: 15
Funder award ID: R01NS097231
OpenAlex ID: G5541964005
Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus
2021 · Li Ma, Jing Wang, et al. · EMBO Reports · 9
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Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis
2021 · Mengfei Yu, Li Ma, et al. · Cell · 160
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Cerebral organoid and mouse models reveal a RAB39b–PI3K–mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes
2020 · Wei Zhang, Li Ma, et al. · Genes & Development · 145
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C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis
2019 · Qiang Shao, Mei Yang, et al. · Autophagy · 63
Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models
2019 · Chen Liang, Qiang Shao, et al. · Human Molecular Genetics · 20
Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
2019 · Wei Zhang, Si-Lu Yang, et al. · Nature Communications · 196
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C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner
2019 · Qiang Shao, Chen Liang, et al. · Acta Neuropathologica Communications · 79
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Lin28-mediated promotion of protein synthesis is critical for neural progenitor cell maintenance and brain development in mice
2019 · Stephanie Herrlinger, Qiang Shao, et al. · Development · 31
Establishing Mouse Models for Zika Virus-induced Neurological Disorders Using Intracerebral Injection Strategies: Embryonic, Neonatal, and Adult
2018 · Stephanie A. Herrlinger, Qiang Shao, et al. · Journal of Visualized Experiments · 5
Selective Lesioning of Nuclear Factor-κB Activated Cells in the Nucleus Accumbens Shell Attenuates Alcohol Place Preference
2017 · S E Nennig, H D Fulenwider, et al. · Neuropsychopharmacology · 11
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The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and Dengue virus
2017 · Qiang Shao, Stephanie Herrlinger, et al. · Development · 97
Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage
2016 · Qiang Shao, Stephanie Herrlinger, et al. · Development · 204
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
2016 · Mei Yang, Chen Liang, et al. · Science Advances · 254
MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation
2015 · Si-Lu Yang, Mei Yang, et al. · Developmental Biology · 43
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
2015 · Mei Yang, Si-Lu Yang, et al. · Development · 127
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