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Integrated Personalized Epigenome Profiling and the Effect of Dietary Exposure on Individuals at Risk for Type-2-Diabetes

Description: PUBLIC HEALTH RELEVANCE: Growing evidence suggests that disease risk is dictated by complex interactions between an individual's genome and environmental factors. Here we aim to identify mechanisms by which dietary exposure, a key environmental factor, influences the genome in individuals at risk for developing type-2- diabetes. We hypothesize that changes in diet will correlate with measurable, dynamic epigenetic signatures that may be used as clinically-relevant biomarkers for both dietary exposure and disease.
Funding type: fellowship
Funder scheme: F32
Start date: 2015-09-28
End date: 2018-09-27
Investigator: KEVIN VAN BORTLE
Institution: STANFORD UNIVERSITY
Funded outputs count: 5
Funder award ID: F32DK107112
OpenAlex ID: G5625840826
Faculty Opinions recommendation of Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development.
2019 · Amy Kenter · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid
2018 · Qing Liu, Kevin Van Bortle, et al. · Scientific Reports · 27
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Topological organization and dynamic regulation of human tRNA genes during macrophage differentiation
2017 · Kevin Van Bortle, Douglas H. Phanstiel, et al. · Genome biology · 50
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Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development
2017 · Douglas H. Phanstiel, Kevin Van Bortle, et al. · Molecular Cell · 313
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Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs
2017 · Qing Liu, Chao Jiang, et al. · Circulation Research · 130
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