Get started
Award

Dll4 in macrophage activation

Description: Project Narrative Inflammation in coronary arteries triggers acute complications of atherosclerosis (e.g., heart attack). However, the mechanism for arterial inflammation remains incompletely understood. We previously used cell culture systems that Delta-like 4 (Dll4) triggers inflammation. The present study will perform mouse experiments to dissect the new mechanisms of inflammation and atherosclerosis. The potential outcomes will offer new therapeutic targets for vascular diseases and contribute to preventive cardiovascular medicine.
Funding type: research
Funder scheme: R01
Start date: 2012-01-01
End date: 2015-11-30
Investigator: MASANORI AIKAWA
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Immunology
Funded outputs count: 31
Funder award ID: R01HL107550
OpenAlex ID: G5772064934
Nuclear RSK1 mediates interferon-γ–induced proinflammatory activation in human primary macrophages and humanized mice
2026 · Keishi Nihira, Yoshihiro Yanagihara, et al. · Science Advances
A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling
2022 · Julius L. Decano, Yukio Iwamoto, et al. · Cell Reports · 48
PDF
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development
2021 · Julius L. Decano, Sasha A. Singh, et al. · Circulation · 39
PDF
Effects of Replacing Dietary Monounsaturated Fat With Carbohydrate on HDL (High-Density Lipoprotein) Protein Metabolism and Proteome Composition in Humans
2019 · Allison B. Andraski, Sasha A. Singh, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 27
Regional pulmonary perfusion patterns in humans are not significantly altered by inspiratory hypercapnia
2019 · Amran K. Asadi, Rui Carlos Sá, et al. · Journal of Applied Physiology · 7
After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology
2019 · Joshua D. Hutcheson, Craig J. Goergen, et al. · Frontiers in Cardiovascular Medicine · 2
PDF
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling
2018 · Toshiaki Nakano, Shunsuke Katsuki, et al. · Circulation · 212
PDF
Dynamic Macrophages: Understanding Mechanisms of Activation as Guide to Therapy for Atherosclerotic Vascular Disease
2018 · Julius L. Decano, Masanori Aikawa · Frontiers in Cardiovascular Medicine · 28
PDF
Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men
2017 · Claudia Goettsch, Hiroshi Iwata, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 58
PDF
Unbiased and targeted mass spectrometry for the HDL proteome
2016 · Sasha A. Singh, Masanori Aikawa · Current Opinion in Lipidology · 19
Automation of PRM‐dependent D3‐Leu tracer enrichment in HDL to study the metabolism of apoA‐I, LCAT and other apolipoproteins
2016 · Lang Ho Lee, Allison B. Andraski, et al. · PROTEOMICS · 6
Quantification of Calcified Particles in Human Valve Tissue Reveals Asymmetry of Calcific Aortic Valve Disease Development
2016 · Katsumi Yabusaki, Joshua D. Hutcheson, et al. · Frontiers in Cardiovascular Medicine · 16
PDF
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
2016 · Hiroshi Iwata, Claudia Goettsch, et al. · Nature Communications · 283
PDF
Delta-Like Ligand 4-Notch Signaling in Macrophage Activation
2016 · Toshiaki Nakano, Daiju Fukuda, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 69
PDF
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification
2016 · Claudia Goettsch, Joshua D. Hutcheson, et al. · Atherosclerosis · 129
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles
2016 · Claudia Goettsch, Joshua D. Hutcheson, et al. · Journal of Clinical Investigation · 259
PDF
Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring
2016 · Sasha A. Singh, Allison B. Andraski, et al. · Journal of Lipid Research · 41
Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development
2015 · Jun-ichiro Koga, Toshiaki Nakano, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 52
Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease
2015 · Manabu Shibasaki, Jian-Guo Wang, et al. · PLoS ONE · 18
PDF
N-acetylglucosamine-1-Phosphate Transferase Suppresses Lysosomal Hydrolases in Dysfunctional Osteoclasts: A Potential Mechanism for Vascular Calcification
2015 · Yang Lei, Masaya Iwashita, et al. · Journal of Cardiovascular Development and Disease · 7
PDF
Many Faces of Matrix Metalloproteinases in Aortic Aneurysms
2015 · Hong Lu, Masanori Aikawa · Arteriosclerosis Thrombosis and Vascular Biology · 24
PDF
Selective Cathepsin S Inhibition Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice with Chronic Renal Disease
2015 · Jose-Luiz Figueiredo, Masanori Aikawa, et al. · American Journal Of Pathology · 85
PDF
Niemann-Pick C1 Affects the Gene Delivery Efficacy of Degradable Polymeric Nanoparticles
2014 · Ahmed A. Eltoukhy, Gaurav Sahay, et al. · ACS Nano · 28
PDF
Plasma Pentraxin 3 Levels Do Not Predict Coronary Events but Reflect Metabolic Disorders in Patients with Coronary Artery Disease in the CARE Trial
2014 · Tetsuro Miyazaki, Stephanie Chiuve, et al. · PLoS ONE · 20
PDF
A Novel Quantitative Approach for Eliminating Sample-To-Sample Variation Using a Hue Saturation Value Analysis Program
2014 · Katsumi Yabusaki, Tyler Faits, et al. · PLoS ONE · 20
PDF
Year
Topic