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Phospholipid metabolism in Leishmania

Description: Leishmania parasites cause 0.7-1.3 million new cases and 50000-90000 deaths each year. Current treatments are inadequate and more research on Leishmania biology is needed to develop new drugs. The goal of this AREA grant is to better understand lipid metabolism in Leishmania and provide rigorous biomedical research training to undergraduate and graduate students at Texas Tech University.
Funding type: research
Funder scheme: R15
Start date: 2021-09-01
End date: 2027-08-31
Investigator: KAI ZHANG
Institution: TEXAS TECH UNIVERSITY
Field: Medicine
Funded outputs count: 7
Funder award ID: R15AI156746
OpenAlex ID: G577334394
Functional Dissection of Leishmania major Membrane Components in Resistance to Cholesterol-Dependent Cytolysins
2026 · Chaitanya S. Haram, Sebastian J. Salinas, et al. · Toxins · 2
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C14DM Ablation Leads to Reduced Tolerance to Plasma Membrane Stress and Increased Drug Sensitivity in Leishmania major
2025 · Samrat Moitra, Sumit Mukherjee, et al. · International Journal of Molecular Sciences · 2
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CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles
2024 · Yiru Jin, Somrita Basu, et al. · Nature Communications · 15
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Molecular Characterization of Sterol C4-Methyl Oxidase in Leishmania major
2024 · Yu Ning, Somrita Basu, et al. · International Journal of Molecular Sciences · 5
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Editorial: Lipids in host and protozoan parasite interaction
2023 · Silvia Haase, Lesly Temesvari, et al. · Frontiers in Cellular and Infection Microbiology · 3
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Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major
2023 · Somrita Basu, Mattie Pawlowic, et al. · PLoS Pathogens · 5
Balancing de novo synthesis and salvage of lipids by Leishmania amastigotes
2021 · Kai Zhang · Current Opinion in Microbiology · 22
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