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Regulation of TLR4 Signaling in Enterocytes in Necrotizing Enterocolitis

Funding type: fellowship
Funder scheme: F30
Start date: 2009-09-01
End date: 2014-08-31
Investigator: AMIN AFRAZI
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Funded outputs count: 13
Funder award ID: F30DK085930
OpenAlex ID: G5807106977
Discovery and Validation of a New Class of Small Molecule Toll-Like Receptor 4 (TLR4) Inhibitors
2013 · Matthew D. Neal, Hongpeng Jia, et al. · PLoS ONE · 138
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Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling
2013 · Ibrahim Yazji, Chhinder P. Sodhi, et al. · Proceedings of the National Academy of Sciences · 248
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A Critical Role for TLR4 Induction of Autophagy in the Regulation of Enterocyte Migration and the Pathogenesis of Necrotizing Enterocolitis
2013 · Matthew D Neal, Chhinder P Sodhi, et al. · The Journal of Immunology · 147
Innate Immune Signaling in the Pathogenesis of Necrotizing Enterocolitis
2013 · David J. Hackam, Amin Afrazi, et al. · Clinical and Developmental Immunology · 91
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Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis
2012 · Julia Arciero, G. Bard Ermentrout, et al. · Journal of Theoretical Biology · 29
Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis
2012 · Matthew D. Neal, Chhinder P. Sodhi, et al. · Journal of Biological Chemistry · 226
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Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice
2012 · Chhinder P. Sodhi, Matthew D. Neal, et al. · Gastroenterology · 329
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Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium
2012 · Misty Good, Richard H. Siggers, et al. · Proceedings of the National Academy of Sciences · 177
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Mammalian DNA Is an Endogenous Danger Signal That Stimulates Local Synthesis and Release of Complement Factor B
2012 · David J. Kaczorowski, Melanie J. Scott, et al. · Molecular Medicine · 28
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Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium
2012 · Amin Afrazi, Chhinder P Sodhi, et al. · The Journal of Immunology · 91
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New Insights Into the Pathogenesis and Treatment of Necrotizing Enterocolitis: Toll-Like Receptors and Beyond
2010 · Amin Afrazi, Chhinder P Sodhi, et al. · Pediatric Research · 134
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Nucleotide-Binding Oligomerization Domain-2 Inhibits Toll-Like Receptor-4 Signaling in the Intestinal Epithelium
2010 · Ward M. Richardson, Chhinder P. Sodhi, et al. · Gastroenterology · 114
Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms
2010 · David J Kaczorowski, Amin Afrazi, et al. · Journal of Leukocyte Biology · 39
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