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Molecular Mechanisms of Social Behavior

Description: PROJECT NARRATIVE Foxes bred for tameness, unlike their wild ancestors, respond in a positive, friendly manner towards humans, just as domesticated dogs, unlike their wolf ancestors, are friendly to people. This project studies the genetics of these inherited fox behaviors in order to understand the causes and mechanisms involved and to potentially gain broader insight into a range of human neurological disorders that are characterized by impaired social reciprocity or by anxiety-related and/or aggressive behaviors.
Funding type: research
Funder scheme: R01
Start date: 2016-09-26
End date: 2021-06-30
Investigator: ANNA KUKEKOVA
Institution: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
Subfield: Genetics
Funded outputs count: 15
Funder award ID: R01GM120782
OpenAlex ID: G5874051663
Congenital spongiform leukodystrophy in 2 female littermate German shepherd puppies
2024 · Ricardo De Miguel, Devon Wallis Hague, et al. · Journal of Veterinary Internal Medicine · 1
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Defining hippocampal area CA2 in the fox ( Vulpes vulpes ) brain
2023 · Serena M. Dudek, Ashley N. Phoenix, et al. · Hippocampus · 2
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The brain of the silver fox (Vulpes vulpes): a neuroanatomical reference of cell-stained histological and MRI images
2023 · Christina N. Rogers Flattery, Munawwar Abdulla, et al. · Brain Structure and Function · 8
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Neuromorphological Changes following Selection for Tameness and Aggression in the Russian Farm-Fox experiment
2021 · Erin E. Hecht, Anna Kukekova, et al. · Journal of Neuroscience · 34
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Hypothalamic transcriptome of tame and aggressive silver foxes ( Vulpes vulpes ) identifies gene expression differences shared across brain regions
2019 · Cheryl S. Rosenfeld, Jessica P. Hekman, et al. · Genes Brain & Behavior · 32
The Red Fox Y-Chromosome in Comparative Context
2019 · Halie M. Rando, William H. Wadlington, et al. · Genes · 6
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Effect of selection for interspecific behavior on stress and conspecific behavior in tame and aggressive foxes
2019 · Ford, Alexandra · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
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Red Fox (Vulpes vulpes) Y-Chromosome Sequence
2019 · Rando, Halie, Wadlington, William, et al.
Four structural variants associated with human‐directed sociability in dogs are not found in tame red foxes (Vulpes vulpes)
2018 · Estelle R. Bastounes, Halie M. Rando, et al. · Animal Genetics
Genomic responses to selection for tame/aggressive behaviors in the silver fox ( Vulpes vulpes )
2018 · Xu Wang, Lenore Pipes, et al. · Proceedings of the National Academy of Sciences · 100
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Red fox genome assembly identifies genomic regions associated with tame and aggressive behaviours
2018 · Anna V. Kukekova, Jennifer L. Johnson, et al. · Nature Ecology & Evolution · 145
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Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly
2018 · Halie M. Rando, Marta Farré, et al. · Genes · 11
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Anterior Pituitary Transcriptome Suggests Differences in ACTH Release in Tame and Aggressive Foxes
2018 · Jessica P Hekman, Jennifer L Johnson, et al. · G3 Genes Genomes Genetics · 36
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Development of a genotype‐by‐sequencing immunogenetic assay as exemplified by screening for variation in red fox with and without endemic rabies exposure
2017 · Michael E. Donaldson, Yessica Rico, et al. · Ecology and Evolution · 8
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Y-Chromosome Markers for the Red Fox
2017 · Halie M Rando, Jeremy T Stutchman, et al. · Journal of Heredity · 15
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