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Core Center for Musculoskeletal Disorders

Description: The Penn Center for Musculoskeletal Disorders will provide opportunities to integrate multi-disciplinary techniques to determine mechanisms for tissue function, injury, and repair, with an ultimate goal to advance the ability to diagnose, treat, and prevent diseases and injuries of the musculoskeletal system and its component tissues.
Funding type: program
Funder scheme: P30
Start date: 2006-07-01
End date: 2016-06-30
Investigator: LOUIS J SOSLOWSKY
Institution: UNIVERSITY OF PENNSYLVANIA
Funded outputs count: 310
Funder award ID: P30AR050950
OpenAlex ID: G5909585136
YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair
2025 · Madhura P. Nijsure, Brendan Tobin, et al. · Science Advances · 8
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Multiscale characterization of jawbone treated with osteoporosis therapeutic agents
2025 · Keiichiro Watanabe, Cheol-Min Han, et al. · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · 3
YAP regulates periosteal expansion in fracture repair
2024 · Madhura P Nijsure, Brendan Tobin, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Single cell RNA sequencing reveals emergent notochord‐derived cell subpopulations in the postnatal nucleus pulposus
2023 · Chenghao Zhang, Leilei Zhong, et al. · The FASEB Journal · 12
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Diabetes impairs fracture healing through Foxo1 mediated disruption of ciliogenesis
2023 · Zahra Chinipardaz, Gongsheng Yuan, et al. · Cell Death Discovery · 11
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Diabetes impairs fracture healing through disruption of cilia formation in osteoblasts
2021 · Zahra Chinipardaz, Min Liu, et al. · Bone · 22
BMP signaling and skeletal development in fibrodysplasia ossificans progressiva ( FOP )
2021 · Oscar Will Towler, Eileen M. Shore · Developmental Dynamics · 28
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Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP)
2020 · O. Will Towler, Sun H. Peck, et al. · Developmental Biology · 19
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Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function
2020 · Yayoi Izu, Sheila M. Adams, et al. · Matrix Biology · 82
Collagen XI regulates the acquisition of collagen fibril structure, organization and functional properties in tendon
2020 · Mei Sun, Eric Y. Luo, et al. · Matrix Biology · 93
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Modulation of vascular response after injury in the rat Achilles tendon alters healing capacity
2020 · Corinne N. Riggin, Ashley B. Rodriguez, et al. · Journal of Orthopaedic Research® · 17
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The Inner Annulus Fibrosus Encroaches on the Nucleus Pulposus in the Injured Mouse Tail Intervertebral Disc
2020 · Yulong Wei, Zuozhen Tian, et al. · American Journal of Physical Medicine & Rehabilitation · 9
Functional Deficits in Mice Expressing Human Interleukin 8
2020 · Julie Michelle Brent, Zuozhen Tian, et al. · Comparative Medicine · 6
Influence of Genetic Background and Sex on Gene Expression in the Mouse (Mus musculus) Tail in a Model of Intervertebral Disc Injury
2020 · Julie M Brent, Zuozhen Tian, et al. · Comparative Medicine · 11
Therapeutic potential of TNFα inhibitors in chronic inflammatory disorders: Past and future
2020 · Hongtao Zhang, Nelson Shi, et al. · Genes & Diseases · 62
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Cleft lip and cleft palate (CL/P) in Esrp1 KO mice is associated with alterations in epithelial-mesenchymal crosstalk
2020 · SungKyoung Lee, Matthew J. Sears, et al. · Development · 43
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Spatial distribution of type II collagen gene expression in the mouse intervertebral disc
2019 · Yulong Wei, Robert J. Tower, et al. · JOR Spine · 13
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IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF-β Signaling in Chondrocyte Differentiation and Function
2019 · Min Liu, Mohammed Alharbi, et al. · Journal of Bone and Mineral Research · 43
Aberrant mechanosensing in injured intervertebral discs as a result of boundary-constraint disruption and residual-strain loss
2019 · Edward D. Bonnevie, Sarah E. Gullbrand, et al. · Nature Biomedical Engineering · 79
YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling
2019 · Christopher D Kegelman, Jennifer C Coulombe, et al. · Journal of Bone and Mineral Research · 95
Non-immunogenic utrophin gene therapy for the treatment of muscular dystrophy animal models
2019 · Yafeng Song, Leon Morales, et al. · Nature Medicine · 97
Tendon Biomechanics and Crimp Properties Following Fatigue Loading Are Influenced by Tendon Type and Age in Mice
2019 · Andrey Zuskov, Benjamin R. Freedman, et al. · Journal of Orthopaedic Research® · 37
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Elevated BMP and Mechanical Signaling Through YAP1/RhoA Poises FOP Mesenchymal Progenitors for Osteogenesis
2019 · Alexandra Stanley, Su-jin Heo, et al. · Journal of Bone and Mineral Research · 47
Ultrasound‐Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage
2019 · Corinne N. Riggin, Mengcun Chen, et al. · Journal of Orthopaedic Research® · 28
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Ultrasound Evaluation of Anti-Vascular Endothelial Growth Factor–Induced Changes in Vascular Response Following Tendon Injury
2019 · Corinne N Riggin, Susan M Schultz, et al. · Ultrasound in Medicine & Biology · 12
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