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Development of TCR-based immunotherapies targeting hotspot EGFR mutations for the treatment of non-small cell lung cancer

Description: Head and Neck, Lung and Bronchus, Skin
Amount: $250,000
Funding type: grant
Funder scheme: Academic Research
Start date: 2021-08-18
Investigator: Alexandre Reuben
Institution: The University of Texas M.D. Anderson Cancer Center
Funded outputs count: 7
Funder award ID: RP210137
OpenAlex ID: G6051116640
Distinct spatial immune architectures in tumor and tumor-adjacent tissues of early-stage non-small cell lung cancer
2026 · Isabella Polic, Claudio Arrechedera, et al. · Frontiers in Immunology
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HER2 mutation–derived neoantigens in NSCLC as actionable targets for TCR therapy
2026 · Amanda Montoya, Hui Nie, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Dual-degenerate TCRs target multiple KRAS hotspot and HLA-A3 family combinations
2026 · Minying Zhang, Barbara Nassif Rausseo, et al. · Research Square
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FOXM1-Specific TCR-Engineered T Cells Target Non–Small Cell Lung Cancer
2026 · Emily Bontekoe, Minying Zhang, et al. · Cancer Immunology Research · 4
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TCR-pMHC Binding Specificity Prediction From Structure Using Graph Neural Networks
2025 · Jared K. Slone, Anja Conev, et al. · IEEE Transactions on Computational Biology and Bioinformatics · 16
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T-Cell Receptor Repertoire Sequencing in the Era of Cancer Immunotherapy
2022 · Meredith L. Frank, Kaylene Lu, et al. · Clinical Cancer Research · 77
Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma
2022 · Runzhe Chen, Jun Li, et al. · Journal of Experimental & Clinical Cancer Research · 10
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