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Molecular Pathogenesis of Monoclonal B Cell Lymphocytosis and CLL

Description: Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United States, with approximately 90,000 affected individuals and 4,500 attributable deaths per year. Monoclonal B lymphocytosis is an identified precursor state for CLL, and is approximately 100 times more prevalent than CLL. The experiments described herein will clarify the biology of pre-emergent CLL, discover the determinants of progression from MBL to CLL, and identify novel targets for therapeutic intervention in CLL.
Funding type: career_development
Funder scheme: K08
Start date: 2011-08-01
End date: 2016-07-31
Investigator: MARK C LANASA
Institution: DUKE UNIVERSITY
Subfield: Genetics
Field: Medicine
Funded outputs count: 18
Funder award ID: K08CA134919
OpenAlex ID: G6134872255
Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes
2022 · Sonja I. Berndt, Joseph Vijai, et al. · Leukemia · 32
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Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes
2021 · Amy Moore, Mitchell J. Machiela, et al. · Journal of Translational Genetics and Genomics
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Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families
2020 · Susan L. Slager, Mark C. Lanasa, et al. · Blood · 37
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Genetically Determined Height and Risk of Non-hodgkin Lymphoma
2020 · Amy Moore, Eleanor Kane, et al. · Frontiers in Oncology · 8
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Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes
2019 · Lennox Din, Mohammad Sheikh, et al. · Genetic Epidemiology · 38
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HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes
2018 · Sophia S. Wang, Mary Carrington, et al. · Cancer Research · 37
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Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
2017 · Sasha Bernatsky, Héctor A Velásquez García, et al. · Lupus Science & Medicine · 28
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Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
2017 · Philip J. Law, Sonja I. Berndt, et al. · Nature Communications · 97
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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
2016 · Sonja I. Berndt, Nicola J. Camp, et al. · Nature Communications · 112
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Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes
2016 · Mitchell J. Machiela, Qing Lan, et al. · Human Molecular Genetics · 58
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Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial andin vitrostudies
2013 · Daphne R. Friedman, Mark C. Lanasa, et al. · Leukemia & lymphoma/Leukemia and lymphoma · 33
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
2013 · Sonja I Berndt, Christine F Skibola, et al. · Nature Genetics · 205
Mapping of the IRF8 Gene Identifies a 3′UTR Variant Associated with Risk of Chronic Lymphocytic Leukemia but not Other Common Non-Hodgkin Lymphoma Subtypes
2013 · Susan L. Slager, Sara J. Achenbach, et al. · Cancer Epidemiology Biomarkers & Prevention · 14
Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia
2013 · Scott J. Hebbring, Susan L. Slager, et al. · Blood · 11
Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non‐ H odgkin lymphoma subtypes
2012 · Susan L. Slager, Nicola J. Camp, et al. · British Journal of Haematology · 16
Single nucleotide polymorphisms and inherited risk of chronic lymphocytic leukemia among African Americans
2012 · Catherine C. Coombs, Laura Z. Rassenti, et al. · Blood · 20
Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia
2012 · Susan L. Slager, Christine F. Skibola, et al. · Blood · 74
Chronic lymphocytic leukemia in African Americans
2012 · Catherine C. Coombs, Lorenzo Falchi, et al. · Leukemia & lymphoma/Leukemia and lymphoma · 24
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