Development of Quantitative Cerebral Blood Flow and Oxygen Metabolism using O-17 Water and Oxygen Molecules
Description: Signal simulations for the various tissue were conducted using theoretical equations of MRI signals. Good correlations were noted between signal simulation and O-17 phantom signal, and conversion method from MRI signal to O-17 concentration was determined. Based on the MRI scans of normal volunteers, scan method with FSE sequence was established, and development of algorithm for quantitative analysis of cerebral blood flow.Manufacturing of O-17 oxygen was established, and inhalation apparatus of O-17 was designed. Smaller O-17 phantom was created, and MRI scans with animal MRI were performed. Good image contrast was obtained for marmosets with the administration of O-17 water.
Amount: ¥16,380,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (B)
Start date: 2014-04-01
End date: 2017-03-31
Investigator: Kohsuke Kudo (lead)
Institution: Hokkaido University
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Funded outputs count: 8
Funder award ID: 26293269
OpenAlex ID: G6180621114