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Mechanisms of UVA-induced skin cancer

Description: Project Narrative Although much progress has been made in the last decades, the number of skin cancer cases continues to increase. In humans and in mice, a tumor suppressor protein, PTEN, contributes to skin cancer risk and is down-regulated by the ultraviolet A (UVA) radiation. Understanding how PTEN is regulated when we are exposed to UVA and its consequences in skin cancer will improve our ability to reduce the disease burden of this most common cancer.

Funder: National Institute of Environmental Health Sciences

Funding type: research

Funder scheme: R01

Start date: 2010-08-09

End date: 2016-03-31

Investigator: YU-YING HE

Institution: UNIVERSITY OF CHICAGO

Topic: Skin Protection and Aging

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 44

Funder award ID: R01ES016936

OpenAlex ID: G6182060751

Autophagy regulates tumor growth and metastasis

2023 · Lei Qiang, Baozhong Zhao, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3

Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair

2018 · Palak Shah, Baozhong Zhao, et al. · Nucleic Acids Research · 24

Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage

2017 · Palak Shah, Lei Qiang, et al. · Oncotarget · 27

Epidermal SIRT1 regulates inflammation, cell migration, and wound healing

2017 · Lei Qiang, Ashley Sample, et al. · Scientific Reports · 82

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis

2017 · Lei Qiang, Ashley Sample, et al. · Autophagy · 111

Adaptor protein p62 promotes skin tumor growth and metastasis and is induced by UVA radiation

2017 · Ashley Sample, Baozhong Zhao, et al. · Journal of Biological Chemistry · 29

The Autophagy Receptor Adaptor p62 is Up‐regulated by UVA Radiation in Melanocytes and in Melanoma Cells

2017 · Ashley Sample, Baozhong Zhao, et al. · Photochemistry and Photobiology · 31

Mechanisms and prevention of UV ‐induced melanoma

2017 · Ashley Sample, Yu‐Ying He · Photodermatology Photoimmunology & Photomedicine · 373

Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer

2017 · Palak Shah, Elaine Trinh, et al. · Molecules · 44

NF-κB Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance

2017 · Seungwon Yang, Lei Qiang, et al. · Journal of Biological Chemistry · 60

Autophagy in UV Damage Response

2016 · Ashley Sample, Yu‐Ying He · Photochemistry and Photobiology · 90

Distinct Role of Sesn2 in Response to UVB‐Induced DNA Damage and UVA‐Induced Oxidative Stress in Melanocytes

2016 · Baozhong Zhao, Palak Shah, et al. · Photochemistry and Photobiology · 44

Mitochondrial dysfunction activates the AMPK signaling and autophagy to promote cell survival

2016 · Baozhong Zhao, Lei Qiang, et al. · Genes & Diseases · 88

Autophagy positively regulates DNA damage recognition by nucleotide excision repair

2015 · Lei Qiang, Baozhong Zhao, et al. · Autophagy · 102

TGF-β signaling links E-cadherin loss to suppression of nucleotide excision repair

2015 · L Qiang, P Shah, et al. · Oncogene · 29

Molecular Regulation of UV ‐Induced DNA Repair

2014 · Palak Shah, Yu‐Ying He · Photochemistry and Photobiology · 75

Sestrin2 Protein Positively Regulates AKT Enzyme Signaling and Survival in Human Squamous Cell Carcinoma and Melanoma Cells

2014 · Baozhong Zhao, Palak Shah, et al. · Journal of Biological Chemistry · 61

Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge

2014 · Mei Ming, Baozhong Zhao, et al. · Journal of Allergy and Clinical Immunology · 63

SIRT6 Promotes COX-2 Expression and Acts as an Oncogene in Skin Cancer

2014 · Mei Ming, Weinong Han, et al. · Cancer Research · 113

Ultraviolet radiation-induced non-melanoma skin cancer: Regulation of DNA damage repair and inflammation

2014 · InYoung Kim, Yu-Ying He · Genes & Diseases · 222

Autophagy deficiency stabilizes TWIST1 to promote epithelial-mesenchymal transition

2014 · Lei Qiang, Yu-Ying He · Autophagy · 80

Effect of Immunosuppressants Tacrolimus and Mycophenolate Mofetil on the Keratinocyte UVB Response

2014 · Mei Ming, Baozhong Zhao, et al. · Photochemistry and Photobiology · 32

RETRACTED: Regulation of cell proliferation and migration by p62 through stabilization of Twist1

2014 · Lei Qiang, Baozhong Zhao, et al. · Proceedings of the National Academy of Sciences · 215

Dual role of SIRT1 in UVB-induced skin tumorigenesis

2014 · M Ming, K Soltani, et al. · Oncogene · 56

Mammalian SIRT 2 inhibits keratin 19 expression and is a tumor suppressor in skin

2014 · Mei Ming, Lei Qiang, et al. · Experimental Dermatology · 45