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Multiscale Modeling of Polymer Based Gene Delivery

Description: The long-term goal of this project is to facilitate rationale design of polymer-based non-viral gene delivery systems by providing critical information inaccessible in experiments with the use of computational approaches. Success in the project will impact gene therapy, a technique that holds great promise for the treatment of a variety of inherited or acquired diseases.
Funding type: research
Funder scheme: R15
Start date: 2013-06-01
End date: 2017-05-31
Investigator: YONGMEI WANG
Institution: UNIVERSITY OF MEMPHIS
Funded outputs count: 10
Funder award ID: R15GM106346
OpenAlex ID: G6182552290
Coarse‐Grained Simulations of the Impact of Chain Length and Stiffness on the Formation and Aggregation of Polyelectrolyte Complexes
2020 · Caleb E. Gallops, Jesse D. Ziebarth, et al. · Macromolecular Theory and Simulations · 8
Phase behavior of supported lipid bilayers: A systematic study by coarse-grained molecular dynamics simulations
2017 · Asma Poursoroush, Maria Maddalena Sperotto, et al. · The Journal of Chemical Physics · 13
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Structural Comparisons of PEI/DNA and PEI/siRNA Complexes Revealed with Molecular Dynamics Simulations
2017 · Jesse D. Ziebarth, Dennis R. Kennetz, et al. · The Journal of Physical Chemistry B · 54
Partial wrapping and spontaneous endocytosis of spherical nanoparticles by tensionless lipid membranes
2016 · Eric J. Spangler, Sudhir Upreti, et al. · The Journal of Chemical Physics · 43
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Modeling and Theory: general discussion
2016 · Guruswamy Kumaraswamy, Vinothan N. Manoharan, et al. · Faraday Discussions · 1
Membrane-mediated aggregation of anisotropically curved nanoparticles
2015 · Alexander D. Olinger, Eric J. Spangler, et al. · Faraday Discussions · 35
Combined effect of cortical cytoskeleton and transmembrane proteins on domain formation in biomembranes
2014 · Md. Kabir Uddin Sikder, Kyle A. Stone, et al. · The Journal of Chemical Physics · 15
Comparison of monovalent and divalent ion distributions around a DNA duplex with molecular dynamics simulation and a Poisson‐Boltzmann approach
2014 · Timothy J. Robbins, Jesse D. Ziebarth, et al. · Biopolymers · 26
Kinetics of domain registration in multicomponent lipid bilayer membranes
2014 · Kan Sornbundit, Charin Modchang, et al. · Soft Matter · 10
Multiscale molecular modeling and rational design of polymer based gene delivery vectors
2011 · Yongmei Wang, Jesse Ziebarth · Journal of Controlled Release · 1
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