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Regulation of Ethanol Effects on Synaptic Transmission

Description: PUBLIC HEALTH RELEVANCE: Despite the importance of the corticotropin-releasing factor and norepinephrine systems in behavioral aspects of drug addiction and withdrawal, the neuronal mechanisms involved in their effects in the amygdala have not been fully delineated. Thus, the present competitive renewal will measure the neuroadaptive changes induced by ethanol dependence and withdrawal in these systems in the amygdala. Determining critical neuroadaptions, and their persistence after ethanol exposure, may be invaluable in the development of pharmacotherapeutics for the treatment of alcoholism.
Funding type: research
Funder scheme: R01
Start date: 2005-04-01
End date: 2021-02-28
Investigator: MARISA ROBERTO
Institution: SCRIPPS RESEARCH INSTITUTE, THE
Funded outputs count: 91
Funder award ID: R01AA015566
OpenAlex ID: G618504357
FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
2022 · Bryan Cruz, Valentina Vozella, et al. · Neuropsychopharmacology · 23
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Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses
2022 · Larry Rodriguez, Dean Kirson, et al. · International Journal of Molecular Sciences · 24
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Ethanol withdrawal-induced adaptations in prefrontal corticotropin releasing factor receptor 1-expressing neurons regulate anxiety and conditioned rewarding effects of ethanol
2022 · Reesha R. Patel, Sarah A. Wolfe, et al. · Molecular Psychiatry · 32
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New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting
2022 · Shanawaj Khair, Lisa A. Brenner, et al. · Alcohol · 8
The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder
2022 · Florence P. Varodayan, Reesha R. Patel, et al. · Biological Psychiatry · 41
Central amygdala corticotropin-releasing factor neurons promote hyponeophagia but do not control alcohol drinking in mice
2022 · Max Kreifeldt, Melissa A. Herman, et al. · Molecular Psychiatry · 21
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The Synaptic Interactions of Alcohol and the Endogenous Cannabinoid System
2022 · S Wolfe · Alcohol research · 22
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Synaptic effects of IL-1β and CRF in the central amygdala after protracted alcohol abstinence in male rhesus macaques
2021 · Reesha R. Patel, Florence P. Varodayan, et al. · Neuropsychopharmacology · 28
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Sex and context differences in the effects of trauma on comorbid alcohol use and post‐traumatic stress phenotypes in actively drinking rats
2021 · Dean Kirson, Michael Q. Steinman, et al. · Journal of Neuroscience Research · 12
Alcohol Dependence in Rats Is Associated with Global Changes in Gene Expression in the Central Amygdala
2021 · Brent R. Kisby, Sean P. Farris, et al. · Brain Sciences · 18
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Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses
2021 · Dean Kirson, Sophia Khom, et al. · Alcohol and Alcoholism · 45
Glucocorticoid Receptor Antagonist Mifepristone Does Not Alter Innate Anxiety-Like Behavior in Genetically-Selected Marchigian Sardinian (msP) Rats
2021 · Valentina Vozella, Bryan Cruz, et al. · International Journal of Molecular Sciences · 16
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Selective inhibition of monoacylglycerol lipase is associated with passive coping behavior and attenuation of stress-induced dopamine release in the medial prefrontal cortex
2021 · Francisco Javier Pavón, Ilham Y. Polis, et al. · Neurobiology of Stress · 18
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Alcohol dependence promotes systemic IFN-γ and IL-17 responses in mice
2020 · Kayla Frank, Shawn Abeynaike, et al. · PLoS ONE · 23
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IL-10 normalizes aberrant amygdala GABA transmission and reverses anxiety-like behavior and dependence-induced escalation of alcohol intake
2020 · Reesha R. Patel, Sarah A. Wolfe, et al. · Progress in Neurobiology · 71
Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically‐selected Marchigian Sardinian alcohol‐preferring rats
2020 · Luis A. Natividad, Michael Q. Steinman, et al. · Addiction Biology · 13
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Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders
2020 · Michael Q. Steinman, Dean Kirson, et al. · Molecular Psychiatry · 37
Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (−)-Bilobalide
2020 · Robert M. Demoret, Meghan A. Baker, et al. · Journal of the American Chemical Society · 72
Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala
2020 · David M. Hedges, Jordan T. Yorgason, et al. · Neuropharmacology · 16
Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala
2020 · Sophia Khom, Sarah A. Wolfe, et al. · Journal of Neuroscience · 44
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Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers
2020 · Anna S. Warden, Sarah A. Wolfe, et al. · Biological Psychiatry · 127
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
2020 · S. Khom, T. Steinkellner, et al. · Science Advances · 28
Corticotropin-Releasing Factor Receptor-1 Neurons in the Lateral Amygdala Display Selective Sensitivity to Acute and Chronic Ethanol Exposure
2020 · Abigail E. Agoglia, ManHua Zhu, et al. · eNeuro · 14
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The Role of the Central Amygdala in Alcohol Dependence
2020 · Marisa Roberto, Dean Kirson, et al. · Cold Spring Harbor Perspectives in Medicine · 115
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Role of MyD88 in IL-1β and Ethanol Modulation of GABAergic Transmission in the Central Amygdala
2019 · Michal Bajo, Reesha R. Patel, et al. · Brain Sciences · 27
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