Role of p53 in Kidney Development: Modeling Renal Anomalies of Li-Fraumeni Patients
Description: PROJECT NARRATIVE Preliminary data indicate that patients with a cancer predisposition syndrome, known as Li-Fraumeni, have an increased prevalence of kidney malformation. Although mutations in the p53 gene cause Li-Fraumeni, it is not known whether these mutations also lead to the kidney anomalies observed in these patients. The proposed study will model Li-Fraumeni mutations in the developing kidney to determine whether p53 disruption interferes with kidney formation.
Funding type: research
Funder scheme: R03
Start date: 2018-08-16
End date: 2021-06-30
Investigator: RACHEL KATHERINE MILLER
Institution: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 14
Funder award ID: R03DK118771
OpenAlex ID: G6186700148