Award

Macrofilaricidal Aminoacyl-tRNA Synthetase Inhibitors

Funder: National Institute of Allergy and Infectious Diseases

Funding type: cooperative_agreement

Funder scheme: U01

Start date: 2002-09-30

End date: 2008-06-30

Investigator: MICHAEL A. KRON

Institution: MEDICAL COLLEGE OF WISCONSIN

Funded outputs count: 17

Funder award ID: U01AI053877

OpenAlex ID: G6214995148

Adipostatins A–D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites

2015 · Mostafa E Rateb, Dong Yang, et al. · The Journal of Antibiotics · 16

Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J

2013 · Mostafa E Rateb, Zhiguo Yu, et al. · The Journal of Antibiotics · 34

Nematode Asparaginyl-tRNA Synthetase Resolves Intestinal Inflammation in Mice with T-Cell Transfer Colitis

2012 · Michael A. Kron, Ahmed Metwali, et al. · Clinical and Vaccine Immunology · 39

Crystallization and preliminary X-ray diffraction analysis of human cytosolic seryl-tRNA synthetase

2010 · Jean-Baptiste Artero, Susana C. M. Teixeira, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 1

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Scoring ligand similarity in structure‐based virtual screening

2009 · Maria I. Zavodszky, Anjali Rohatgi, et al. · Journal of Molecular Recognition · 39

StoneHinge: Hinge prediction by network analysis of individual protein structures

2009 · Kevin S. Keating, Samuel C. Flores, et al. · Protein Science · 51

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Target Flexibility: An Emerging Consideration in Drug Discovery and Design

2008 · Pietro Cozzini, Glen E. Kellogg, et al. · Journal of Medicinal Chemistry · 309

Interconversion between two unrelated protein folds in the lymphotactin native state

2008 · Robbyn L. Tuinstra, Francis C. Peterson, et al. · Proceedings of the National Academy of Sciences · 303

Identification of diadenosine triphosphate in Brugia malayi by reverse phase high performance liquid chromatography and MALDI mass spectrometry

2007 · Michael Kron, Joseph Leykam, et al. · Journal of Chromatography B · 10

Structures of Two Bacterial Prolyl-tRNA Synthetases with and without a cis-Editing Domain

2006 · Thibaut Crepin, Anna Yaremchuk, et al. · Structure · 72

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Structural basis for the enantiospecificities of R‐ and S‐specific phenoxypropionate/α‐ketoglutarate dioxygenases

2006 · Tina A. Müller, Maria I. Zavodszky, et al. · Protein Science · 16

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Brugia malayiAsparaginyl–Transfer RNA Synthetase Induces Chemotaxis of Human Leukocytes and Activates G‐Protein–Coupled Receptors CXCR1 and CXCR2

2006 · Bernadette L. Ramirez, O. M. Zack Howard, et al. · The Journal of Infectious Diseases · 32

Discovering New Classes of Brugia malayi Asparaginyl-tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change

2006 · Sai Chetan K. Sukuru, Thibaut Crepin, et al. · Journal of Computer-Aided Molecular Design · 47

Side‐chain flexibility in protein–ligand binding: The minimal rotation hypothesis

2005 · Maria I. Zavodszky, Leslie A. Kuhn · Protein Science · 172

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Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease?

2005 · Michael A. Kron, Michael Petridis, et al. · Medical Hypotheses · 14

2004 · Maria I. Zavodszky, Ming Lei, et al. · Proteins Structure Function and Bioinformatics · 79

Distilling the essential features of a protein surface for improving protein-ligand docking, scoring, and virtual screening

2002 · Maria I. Zavodszky, Paul C. Sanschagrin, et al. · Journal of Computer-Aided Molecular Design · 94