Subunit Structure and Function of Vacuolar H+-ATPases
Description: V-ATPases present in all cells help control pH, degrade defective proteins, and respond to different types of environmental stress; because of their importance in these functions, they are potential drug targets for neurodegenerative diseases, cancer, and osteoporosis. The proposed experiments use a widely accepted model system to address how V-ATPases in different cellular locations respond to stress and how the activity of V-ATPases is coordinated with activity of other cellular proteins. Our experiments will provide insights into how V-ATPase activity might be increased or decreased to target specific tissues and disease processes.
Funding type: research
Funder scheme: R01
Start date: 1994-03-01
End date: 2018-01-31
Investigator: PATRICIA M KANE (lead)
Institutions: SUNY Upstate Medical University, UPSTATE MEDICAL UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 56
Funder award ID: R01GM050322
OpenAlex ID: G647849026