Award

Protective mechanisms of protein SUMOylation in the heart

Funder: British Heart Foundation

Amount: £282,700

Funding type: research

Funder scheme: Project Grants

Investigator: J Henley (lead)

Institution: University of Bristol

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 11

Funder award ID: PG/14/60/31014

OpenAlex ID: G6617762163

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff)

2019 · Laura Lee, Richard Seager, et al. · PLoS ONE · 15

Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury

2019 · Nadiia Rawlings, Laura Lee, et al. · PLoS ONE · 31

Commentary: Analysis of SUMO1-conjugation at synapses

2017 · Kevin A. Wilkinson, Stéphane Martin, et al. · Frontiers in Cellular Neuroscience · 15

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

2017 · Ashley J. Evans, Sonam Gurung, et al. · Cell Reports · 47

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

2017 · Daniel L. Rocca, Kevin A. Wilkinson, et al. · Scientific Reports · 48

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

2017 · Chun Guo, Kevin A. Wilkinson, et al. · Scientific Reports · 82

Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3–dependent cytotoxicity

2017 · Jia Luo, Sonam Gurung, et al. · The Journal of Toxicological Sciences · 21

Editorial: Ionotropic Glutamate Receptors Trafficking in Health and Disease

2016 · Milos Petrovic, Inmaculada M. Gonzalez-Gonzalez, et al. · Frontiers in Cellular Neuroscience · 1

Ubiquitin C-terminal hydrolase L1 (UCH-L1): structure, distribution and roles in brain function and dysfunction

2016 · Paul Bishop, Dan Rocca, et al. · Biochemical Journal · 330

Synaptic AMPA receptor composition in development, plasticity and disease

2016 · Jeremy M. Henley, Kevin A. Wilkinson · Nature reviews. Neuroscience · 528

Fighting polyglutamine disease by wrestling with SUMO

2015 · Tim J. Craig, Jeremy M. Henley · Journal of Clinical Investigation · 5