Development of catalytic transformations that include multiple bond cleavages and formations
Description: In this study, research on catalytic transformations involving multiple bond cleavages and formations was conducted, and more than ten reactions were developed. Spirobiindanones, arylideneindanes, and dihydrophenanthrenes were synthesized by rhodium-catalyzed arylation. Ring-opening coupling reactions of cyclopropenones afforded alkenyl alkynyl ketones and spirocyclic cyclopentanones. Hydrazine derivatives underwent rhodium-catalyzed cyclization reactions to give indoles and phthalazinones. Maleic anhydrides coupled with alkynes and diynes to afford pyrones and benzenes, respectively. Rhodium-catalyzed reaction of pyridylmethylenecyclobutanes gave indanes through a skeletal rearrangement. On the other hand, pyridylmethylenecyclobutenes underwent rhodium-catalyzed intermolecular coupling with alkynes to afford multisubstituted benzenes.
Amount: ¥5,200,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2013-04-01
End date: 2016-03-31
Investigator: Takanori Matsuda (lead)
Institution: Tokyo University of Science
Topic: Catalytic Alkyne Reactions
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Funded outputs count: 18
Funder award ID: 25410054
OpenAlex ID: G661982136