Genetic correlates of gene and protein expression endophenotypes in the brain areas of schizophrenic patients.
Description: Schizophrenia is a severe mental disorder affecting 1% of the population. According to our hypothesis, certain gene/protein expression endophenotypes in the brain are characteristic to schizophrenia and our purpose is to find corresponding genotype correlates. Our main strategy is to detect gene/protein expression levels and genotype profiles (SNPs) from the same subjects in order to produce data that could be used for the development of diagnostical tools. Modelling schizophrenia in animals is complicated; therefore we concentrate on post mortem human brain tissue samples that will be obtained from an international brain bank. We will focus on candidate genes that have been shown to be implicated in schizophrenia in either animal studies or SNP association studies in humans. Our first gene candidates are the IgLon family of genes. One of the members, Lsamp, is a strong candidate gene for schizophrenia according to our recent association and animal studies.
Funder: Eesti Teadusagentuur
Amount: €216,000
Funding type: grant
Funder scheme: Personal Research Funding (PUT)
Start date: 2013-01-01
End date: 2016-12-31
Investigator: Mari-Anne Philips
Institution: University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine
Funded outputs count: 7
Funder award ID: PUT129
OpenAlex ID: G6957879657