Construction of the experimental model for assessment of motivation using rat intracranial self-stimulation model
Description: In the present study, we constructed the experimental model using the intracranial self-stimulation to evaluate "motivation" and assessed the impact of drug administration on the motivation. The intracranial self-stimulation behavior is one of the experimental method for the assessment of brain reward function.As a result, it was demonstrated that brain dopamine nerves showed an important role in motivation, and that amplifying the action of dopamine which was released from the nerve terminal would be important in improving motivation. In addition, it was suggested that the brain nerve cell was possibility activated by the acquisition of motivated behavior.
Amount: ¥5,070,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2013-04-01
End date: 2016-03-31
Investigator: Sendo Toshiaki (lead)
Institution: Okayama University
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 25460212
OpenAlex ID: G7004067167