Pathophysiology of gastroesophageal reflux in neurologically impaired children
Description: Neurologically impaired(NI) patients showed a wide range of gastric emptying rates without any significant causal relationship between delayed gastric emptying and gastroesophageal reflux(GER). The results suggest that the proximal gastric accommodation, which is caused by adaptive gastric relaxation, is a more important factor for controlling GER than the acceleration of gastric emptying.There was an increase in acid GER in NI pediatric patients with abnormal GER, whereas acid and nonacid GER were comparable in NI pediatric patients without abnormal GER. Although the underlying mechanism of our findings could not be fully explained, physiologically appropriate therapeutic approaches for GER disease in NI patents should include the reduction of acid GER to that of nonacid GER rather than the complete prevention of all GER.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2014-04-01
End date: 2018-03-31
Investigator: Hisayoshi Kawahara (lead)
Institution: Hamamatsu University School of Medicine
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 9
Funder award ID: 26462706
OpenAlex ID: G7064458014