Award

Structure and Mechanism in the Tautomerase Superfamily

Description: Principal Investigator/Program Director (Last, First, Middle): Whitman, Christian P. It is critical to understand how enzymes evolve and acquire new functions due to the prevalence of antibiotic-resistant bacteria and other drug-resistant organisms such as M. tuberculosis and HIV. Drug-resistant organisms have become a major public health threat and will continue to be one. The proposed studies will result in a well-defined model for the evolution of enzymes and enhance our understanding of how resistance evolves in the first place. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page
Funding type: research
Funder scheme: R01
Start date: 2002-04-01
End date: 2013-07-31
Investigator: CHRISTIAN P. WHITMAN
Institution: UNIVERSITY OF TEXAS AT AUSTIN
Subfield: Immunology
Funded outputs count: 32
Funder award ID: R01GM065324
OpenAlex ID: G70710244
2019 · Bert-Jan Baas, Brenda P. Medellin, et al. · Biochemistry · 9
2017 · Jamison P. Huddleston, Susan C. Wang, et al. · Archives of Biochemistry and Biophysics · 2
2014 · Jamison P. Huddleston, William H. Johnson, et al. · Perspectives in Science · 3
2014 · Jamison P. Huddleston, Elizabeth A. Burks, et al. · Archives of Biochemistry and Biophysics · 17
2013 · Gerrit J. Poelarends, Hector Serrano, et al. · FEBS Letters · 4
2013 · Gottfried K. Schroeder, Jamison P. Huddleston, et al. · Biochemistry · 4
2011 · Gottfried K. Schroeder, William H. Johnson, et al. · Journal of the American Chemical Society · 20
2009 · Brooklyn A. Robertson, Gottfried K. Schroeder, et al. · Biochemistry · 9
2009 · Robin Sevastik, Christian P. Whitman, et al. · Biochemistry · 14
2008 · Scott D. Pegan, Hector Serrano, et al. · Acta Crystallographica Section D Biological Crystallography · 3
2008 · G. J. Poelarends, V. Puthan Veetil, et al. · Cellular and Molecular Life Sciences · 92
2006 · René M. de Jong, Paola Bazzacco, et al. · Journal of Biological Chemistry · 36
2005 · Gerrit J. Poelarends, Hector Serrano, et al. · Biochemistry · 21
2004 · Gerrit J. Poelarends, Hector Serrano, et al. · Journal of the American Chemical Society · 36
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