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Development of new biocompatible materials to reduce inflammation

Description: Spacer placement surgery has been shown to be effective in enabling radical particle therapy for abdominal malignant tumors. We have developed an absorbable spacer made of polyglycolic acid processed into a non-woven fabric as a spacer. In the present study, we evaluated inflammatory changes after implantation of absorbable spacer and several anti-adhesive agents (1) Seprafilm, 2) Interseed, and 3) Adspray) in rats in order to investigate the anti-adhesive effect after implantation of the absorbable spacer. Visual and pathological evaluation of adhesions at 7, 14, and 28 days after implantation was performed. Visual evaluation using the Lauder score on day 28 after implantation showed significantly less inflammation in the Seprafilm group, indicating that it may be the most effective in preventing adhesions.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,420,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2018-04-01

End date: 2024-03-31

Investigator: Komatsu Shohei (lead)

Institution: Kobe University

Topic: Intestinal and Peritoneal Adhesions

Subfield: Surgery

Field: Medicine

Domain: Health Sciences