Regulating the sensitivity of lung cancer to immunotherapy through inhibiting neutrophil activation and promoting T cell infiltration in tumors
Description: We investigated the tumor microenvironment in mouse lung cancer, and found that tumor cells recruited neutrophils that suppressed anti-tumor CD8 T cell function as a result of arginine depletion by arginase. Based on this finding, we treated the tumors with an arginase inhibitor. The lung tumor volume was significantly lower in the treated group than in the untreated group. We confirmed that an increased number of neutrophils in the peripheral blood was significantly correlated with a reduced response rate to anti-PD-1 antibody treatment. Therefore, targeting immune-suppressive neutrophils can be a vital option for lung cancer treatment with immune checkpoint inhibitors such as anti-PD-1 antibodies.
Amount: ¥3,380,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Shohei Koyama
Institution: Osaka University
Topic: Bacterial Cancer Therapy
Subfield: Biotechnology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: 17K16045
OpenAlex ID: G7141784875