Get started
Award

Nitric Oxide in Pulmonary Hypertension

Description: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a progressive and often lethal disease that disproportionately affects women. In this project, our goal is to discover the cellular metabolic mechanisms underlying the development and progression of PAH so that we can develop new strategies for treatment of patients.
Funding type: research
Funder scheme: R01
Start date: 1999-04-01
End date: 2025-12-31
Investigator: SERPIL C. ERZURUM
Institution: CLEVELAND CLINIC LERNER COM-CWRU
Funded outputs count: 91
Funder award ID: R01HL060917
OpenAlex ID: G7166330850
Mitochondrial arginase 2 regulates hematopoietic and cardiovascular adaptation to hypoxia
2025 · Weiling Xu, Kewal Asosingh, et al. · Blood Vessels Thrombosis & Hemostasis · 2
Hypoxia responses in arginase 2 deficient mice enhance cardiovascular health
2025 · Weiling Xu, Kewal Asosingh, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Quantification of the pulmonary vasculature in mice under chronic hypoxia with contrast-free pulmonary angiography in vivo imaging
2024 · Samar Farha, Evan Madden, et al. · Journal of Applied Physiology · 2
Alterations in Mitochondrial Function in Pulmonary Vascular Diseases
2024 · Samar Farha, Kewal Asosingh, et al. · Antioxidants and Redox Signaling · 4
PDF
Expression of soluble guanylate cyclase (sGC) and its ability to form a functional heterodimer are crucial for reviving the NO-sGC signaling in PAH
2024 · Mamta P. Sumi, Blair Tupta, et al. · Free Radical Biology and Medicine · 5
Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report
2024 · Rebecca F. Hough, Cristina M. Alvira, et al. · American Journal of Respiratory Cell and Molecular Biology · 11
Dysregulation of the Long Noncoding RNA X-Inactive–Specific Transcript Expression in Male Patients with Pulmonary Arterial Hypertension
2024 · Brandon L. Carman, Shanshan Qin, et al. · American Journal Of Pathology · 13
PDF
Blood Cholesterol and Triglycerides Associate with Right Ventricular Function in Pulmonary Hypertension
2024 · Battoul Fakhry, Laura Peterson, et al. · medRxiv · 4
PDF
Method for depletion of mitochondria DNA in human bronchial epithelial cells
2023 · Michael V. Novotny, Weiling Xu, et al. · MethodsX · 8
Hematopoietic stem cells and extramedullary hematopoiesis in the lungs
2023 · Andrew Reichard, Nicholas Wanner, et al. · Cytometry Part A · 6
PDF
Single-cell transcriptomic profiling of microvascular endothelial cell heterogeneity in congenital diaphragmatic hernia
2023 · Jason O. Robertson, Peter Bazeley, et al. · Scientific Reports · 7
PDF
Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ
2023 · Yu Sun, Kate Stenson, et al. · Circulation Research · 10
PDF
Pathological Roles for Endothelial Colony-Forming Cells in Neonatal and Adult Lung Disease
2022 · Jason O. Robertson, Serpil C. Erzurum, et al. · American Journal of Respiratory Cell and Molecular Biology · 9
A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
2022 · Yadi Zhou, Yuan Liu, et al. · Nature Biotechnology · 203
PDF
Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic
2022 · Arnab Ghosh, Mamta P. Sumi, et al. · Redox Biology · 30
Preclinical Four-Dimensional Functional Lung Imaging and Quantification of Regional Airflow: A New Standard in Lung Function Evaluation in Murine Models
2022 · Kewal Asosingh, Matthew Frimel, et al. · American Journal of Respiratory Cell and Molecular Biology · 19
Menstrual cycle impacts lung structure measures derived from quantitative computed tomography
2021 · Jessica C. Sieren, Kimberly E. Schroeder, et al. · European Radiology · 4
The systemic inflammatory landscape of COVID-19 in pregnancy: Extensive serum proteomic profiling of mother-infant dyads with in utero SARS-CoV-2
2021 · Suan-Sin Foo, Mary Catherine Cambou, et al. · Cell Reports Medicine · 63
Metabolic endophenotype associated with right ventricular glucose uptake in pulmonary hypertension
2021 · Samar Farha, Suzy Comhair, et al. · Pulmonary Circulation · 14
PDF
Cutting Edge: Steroid Responsiveness in Foxp3+ Regulatory T Cells Determines Steroid Sensitivity during Allergic Airway Inflammation in Mice
2021 · Quang Tam Nguyen, Dongkyun Kim, et al. · The Journal of Immunology · 10
Single-cell transcriptomic profile of human pulmonary artery endothelial cells in health and pulmonary arterial hypertension
2021 · Kewal Asosingh, Suzy Comhair, et al. · Scientific Reports · 52
PDF
Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop
2021 · Jane A. Leopold, Steven M. Kawut, et al. · Circulation Heart Failure · 32
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes
2021 · Mehdi Baratchian, Jeffrey M. McManus, et al. · Scientific Reports · 116
PDF
Up-Regulation of the Long Noncoding RNA X-Inactive–Specific Transcript and the Sex Bias in Pulmonary Arterial Hypertension
2021 · Shanshan Qin, Dan Predescu, et al. · American Journal Of Pathology · 26
PDF
Metabolism in Pulmonary Hypertension
2021 · Weiling Xu, Allison J. Janocha, et al. · Annual Review of Physiology · 190
PDF
Year
Topic