Tension-dependent regulation of alpha-catenin during morphogenesis in C. elegans
Description: Relevance Understanding how cells attach to one another is important for understanding many common birth defects, and how cancer cells lose their connections to one another and invade the body. This proposal examines a key protein, a-catenin, that regulates cell adhesiveness, and how this protein works together with a protein known as Tes to ensure that cells make proper connections in the body. By studying how these proteins work in living embryos, we will gain important information that serves as the backdrop for understanding and treating human disease.!
Funding type: research
Funder scheme: R01
Start date: 1998-08-01
End date: 2023-02-28
Investigator: JEFFREY D HARDIN (lead)
Institutions: University of Wisconsin–Madison, UNIVERSITY OF WISCONSIN-MADISON
Funded outputs count: 64
Funder award ID: R01GM058038
OpenAlex ID: G7253994112