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The kallikrein-kinin system in endothelial progenitor cell homing in arthritis

Description: Project Narrative Synovial neovascularization is critical for the pathogenesis of rheumatoid arthritis. The proposed research examines the regulation of endothelial progenitor cells (EPCs) by plasma kallikrein-kinin system and determines the contribution of EPCs to synovial neovascularization. This project will provide novel insight into the mechanism of synovial neovascularization and will identify potential therapeutic targets for treatment of arthritis.
Funding type: research
Funder scheme: R03
Start date: 2009-07-01
End date: 2013-06-30
Investigator: YI WU
Institution: TEMPLE UNIV OF THE COMMONWEALTH
Subfield: Genetics
Field: Medicine
Funded outputs count: 11
Funder award ID: R03AR057542
OpenAlex ID: G7282394936
The Plasma Kallikrein–Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice
2018 · Bo Wang, Aizhen Yang, et al. · Frontiers in Immunology · 25
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A critical role for plasma kallikrein in the pathogenesis of autoantibody‐induced arthritis
2017 · Aizhen Yang, Junsong Zhou, et al. · The FASEB Journal · 20
An essential role of high-molecular-weight kininogen in endotoxemia
2017 · Aizhen Yang, Zhanli Xie, et al. · The Journal of Experimental Medicine · 41
Cleaved high molecular weight kininogen stimulates JNK/FOXO4/MnSOD pathway for induction of endothelial progenitor cell senescence
2014 · Xuemei Zhu, Xichen Zheng, et al. · Biochemical and Biophysical Research Communications · 12
High Molecular Weight Kininogen Binds Phosphatidylserine and Opsonizes Urokinase Plasminogen Activator Receptor–Mediated Efferocytosis
2014 · Aizhen Yang, Jihong Dai, et al. · The Journal of Immunology · 30
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A role for bradykinin in the development of anti-collagen antibody-induced arthritis
2014 · Zhanli Xie, Jihong Dai, et al. · Lara D. Veeken · 27
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Role of plasma kallikrein–kinin system activation in synovial recruitment of endothelial progenitor cells in experimental arthritis
2012 · Jihong Dai, Alexis Agelan, et al. · Arthritis & Rheumatism · 20
Cleaved High-Molecular-Weight Kininogen Accelerates the Onset of Endothelial Progenitor Cell Senescence by Induction of Reactive Oxygen Species
2011 · Jihong Dai, Xuemei Zhu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 26
Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling
2010 · Yi Wu, Yuchuan Liu, et al. · Thrombosis and Haemostasis · 21
Cleaved high molecular weight kininogen inhibits tube formation of endothelial progenitor cells via suppression of matrix metalloproteinase 2
2009 · Y. WU, J. DAI, et al. · Journal of Thrombosis and Haemostasis · 30
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Aldonza Fernández y Álvaro Gutiérrez, nobles asturianos del siglo XII
1991 · María Elida García García · Dialnet (Universidad de la Rioja)
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