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Hormonal signals, genome integrity and longevity

Funding type: research
Funder scheme: R01
Start date: 2001-07-01
End date: 2011-06-30
Investigator: JAN VIJG
Institution: ALBERT EINSTEIN COLLEGE OF MEDICINE
Funded outputs count: 22
Funder award ID: R01AG020438
OpenAlex ID: G3357368892
Deletion of p66 S hc in mice increases the frequency of size‐change mutations in the lac Z transgene
2012 · Elena Beltrami, Antonella Ruggiero, et al. · Aging Cell · 8
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Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila
2011 · Ana Maria Garcia, Robert N Salomon, et al. · Genome biology · 29
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Age- and Temperature-Dependent Somatic Mutation Accumulation in Drosophila melanogaster
2010 · Ana Maria Garcia, R. Brent Calder, et al. · PLoS Genetics · 68
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Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster
2009 · Ursula Edman, Ana Maria Garcia, et al. · Aging Cell · 36
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Genome instability, cancer and aging
2009 · Alexander Y. Maslov, Jan Vijg · Biochimica et Biophysica Acta (BBA) - General Subjects · 128
Mitochondrial DNA mutations and aging: devils in the details?
2008 · Konstantin Khrapko, Jan Vijg · Trends in Genetics · 111
Turning anti-ageing genes against cancer
2008 · Valter D. Longo, Michael R. Lieber, et al. · Nature Reviews Molecular Cell Biology · 36
Homeostatic Imbalance between Apoptosis and Cell Renewal in the Liver of Premature Aging XpdTTD Mice
2008 · Jung Yoon Park, Mi-Ook Cho, et al. · PLoS ONE · 29
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Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues
2008 · Ana Maria Garcia, Rita A. Busuttil, et al. · Mechanisms of Ageing and Development · 70
The role of DNA damage and repair in aging: New approaches to an old problem
2008 · Jan Vijg · Mechanisms of Ageing and Development · 35
Intra-Organ Variation in Age-Related Mutation Accumulation in the Mouse
2007 · Rita A. Busuttil, Ana Maria Garcia, et al. · PLoS ONE · 58
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Genome instability: Cancer or aging?
2007 · Jan Vijg, Martijn E.T. Dollé · Mechanisms of Ageing and Development · 19
A model system for analyzing somatic mutations in Drosophila melanogaster
2007 · Ana Maria Garcia, Anastasia Derventzi, et al. · Nature Methods · 27
Genome dynamics and transcriptional deregulation in aging
2006 · R. Busuttil, R. Bahar, et al. · Neuroscience · 49
Haploinsufficiency in DNA Polymerase β Increases Cancer Risk with Age and Alters Mortality Rate
2006 · Diane C. Cabelof, Yuji Ikeno, et al. · Cancer Research · 70
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Maintaining Genetic Integrity in Aging: A Zero Sum Game
2006 · Yousin Suh, Jan Vijg · Antioxidants and Redox Signaling · 24
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
2006 · Martijn E.T. Dollé, Rita A. Busuttil, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 109
Organ-Specific Increase in Mutation Accumulation and Apoptosis Rate in CuZn-Superoxide Dismutase–Deficient Mice
2005 · Rita A. Busuttil, Ana Maria Garcia, et al. · Cancer Research · 85
Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice
2005 · Rita A. Busuttil, Miguel Rubio, et al. · DNA repair · 33
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SNP discovery in associating genetic variation with human disease phenotypes
2005 · Yousin Suh, Jan Vijg · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 187
Genetics of Longevity and Aging
2005 · Jan Vijg, Yousin Suh · Annual Review of Medicine · 141
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity
2004 · Paul Hasty, Jan Vijg · Aging Cell · 77
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