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三维基质粘弹性影响乳腺癌细胞凋亡和自噬交互作用的力学生物学机制研究

Amount: ¥800,000
Funding type: grant
Funder scheme: 面上项目
Start date: 2017-01-01
End date: 2021-12-31
Investigator: 贻尧 刘
Institution: 电子科技大学
Funded outputs count: 31
Funder award ID: 11772088
OpenAlex ID: G7373676216
Recent Advancements in Serum Albumin-Based Nanovehicles Toward Potential Cancer Diagnosis and Therapy
2021 · Xue Shen, Xiyang Liu, et al. · Frontiers in Chemistry · 77
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Aptamer-Dendrimer Functionalized Magnetic Nano-Octahedrons: Theranostic Drug/Gene Delivery Platform for Near-Infrared/Magnetic Resonance Imaging-Guided Magnetochemotherapy
2021 · Zhongyuan Chen, Yueting Peng, et al. · ACS Nano · 73
Notch‐1 signaling promotes reattachment of suspended cancer cells by cdc42‐dependent microtentacles formation
2021 · Ping Li, Yu Chen, et al. · Cancer Science · 10
Simultaneous 2D and 3D cell culture array for multicellular geometry, drug discovery and tumor microenvironment reconstruction
2021 · Shun Li, Kaifu Yang, et al. · Biofabrication · 52
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Protective autophagy attenuates soft substrate-induced apoptosis through ROS/JNK signaling pathway in breast cancer cells
2021 · Yu Chen, Ping Li, et al. · Free Radical Biology and Medicine · 26
Shear stress triggered circular dorsal ruffles formation to facilitate cancer cell migration
2021 · Xiang Qin, Yuehui Zhang, et al. · Archives of Biochemistry and Biophysics · 11
Zeolitic imidazolate frameworks-based nanomaterials for biosensing, cancer imaging and phototheranostics
2021 · Xiaodan Wei, Ningxi Li, et al. · Applied Materials Today · 33
Soft Substrate Promotes Osteosarcoma Cell Self-Renewal, Differentiation, and Drug Resistance Through miR-29b and Its Target Protein Spin 1
2020 · Shun Li, Hongxia Bai, et al. · ACS Biomaterials Science & Engineering · 39
PLGA-Based Drug Delivery Systems for Remotely Triggered Cancer Therapeutic and Diagnostic Applications
2020 · Xue Shen, Tingting Li, et al. · Frontiers in Bioengineering and Biotechnology · 92
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Cell Membrane Coated-Biomimetic Nanoplatforms Toward Cancer Theranostics
2020 · Tingting Li, Xiang Qin, et al. · Frontiers in Bioengineering and Biotechnology · 35
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A versatile nanoplatform for synergistic chemo-photothermal therapy and multimodal imaging against breast cancer
2020 · Tingting Li, Yue Geng, et al. · Expert Opinion on Drug Delivery · 31
Shear stress stimulates integrin β1 trafficking and increases directional migration of cancer cells via promoting deacetylation of microtubules
2020 · Kai Tang, Shun Li, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 33
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Acid‐Triggered Charge‐Convertible Graphene‐Based All‐in‐One Nanocomplex for Enhanced Genetic Phototherapy of Triple‐Negative Breast Cancer
2019 · Chunhui Wu, Yuan Tian, et al. · Advanced Healthcare Materials · 31
Matrix stiffness modulates ILK-mediated YAP activation to control the drug resistance of breast cancer cells
2019 · Xiang Qin, Xiaoying Lv, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 99
Polymeric Hybrid Nanomicelles for Cancer Theranostics: An Efficient and Precise Anticancer Strategy for the Codelivery of Doxorubicin/miR-34a and Magnetic Resonance Imaging
2019 · Xiaoxue Xie, Yu Chen, et al. · ACS Applied Materials & Interfaces · 38
The tumor biochemical and biophysical microenvironments synergistically contribute to cancer cell malignancy
2019 · Xiang Qin, Tingting Li, et al. · Cellular and Molecular Immunology · 18
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Unveiling the Mechanotransduction Mechanism of Substrate Stiffness‐modulated Cancer Cell Motility via ROCK1 and ROCK2 Differentially Regulated Manner
2019 · Yueting Peng, Yu Chen, et al. · The FASEB Journal · 3
Highly efficient cascading synergy of cancer photo-immunotherapy enabled by engineered graphene quantum dots/photosensitizer/CpG oligonucleotides hybrid nanotheranostics
2019 · Chunhui Wu, Xiaotian Guan, et al. · Biomaterials · 118
Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer
2019 · Tingting Li, Sixiang Shi, et al. · Acta Biomaterialia · 226
NIR-Light-Triggered Anticancer Strategy for Dual-Modality Imaging-Guided Combination Therapy via a Bioinspired Hybrid PLGA Nanoplatform
2019 · Xue Shen, Tingting Li, et al. · Molecular Pharmaceutics · 63
ROCK isoforms differentially modulate cancer cell motility by mechanosensing the substrate stiffness
2019 · Yueting Peng, Zhongyuan Chen, et al. · Acta Biomaterialia · 151
Low shear stress induces ERK nuclear localization and YAP activation to control the proliferation of breast cancer cells
2019 · Xiang Qin, Ji Li, et al. · Biochemical and Biophysical Research Communications · 48
Dendrimer-Functionalized Superparamagnetic Nanobeacons for Real-Time Detection and Depletion of HSP90α mRNA and MR Imaging
2019 · Zhongyuan Chen, Yueting Peng, et al. · Theranostics · 21
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Shear stress promotes anoikis resistance of cancer cells via caveolin‐1‐dependent extrinsic and intrinsic apoptotic pathways
2018 · Shun Li, Yu Chen, et al. · Journal of Cellular Physiology · 68
Acidic pHe regulates cytoskeletal dynamics through conformational integrin β1 activation and promotes membrane protrusion
2018 · Shun Li, Niya Xiong, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 47
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