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Resistance testing versus adherence support for management of patients with virologic failure on first-line antiretroviral therapy in sub-Saharan Africa: An open-label randomized controlled trial

Description: PUBLIC HEALTH RELEVANCE: The President's Emergency Plan for HIV/AIDS Relief has embarked on its third phase, which seeks, in part, to maximize the sustainability of HIV care programs in partner countries. Central to this mission is establishment of effective and affordable strategies for management of virologic failure, an event that has important ramifications for patient health, prevention of HIV transmission, and costs of care. Our proposal will directly address this critical issue by providing much needed data to empower PEPFAR and partner programs to take a data-driven approach to optimize management of virologic failure in sub-Saharan Africa.
Funding type: research
Funder scheme: R01
Start date: 2016-07-01
End date: 2022-06-30
Investigator: WINNIE MUYINDIKE
Institution: MASSACHUSETTS GENERAL HOSPITAL
Field: Medicine
Funded outputs count: 23
Funder award ID: R01AI124718
OpenAlex ID: G7400936846
Extensive diversity and impact of drug-resistant HIV-1 variants in individuals with prior virologic failure
2026 · Melendhran Pillay, Manish C. Choudhary, et al. · PLoS Pathogens · 1
Determinants of health-related quality of life in people with Human Immunodeficiency Virus, failing first-line treatment in Africa
2023 · Tamlyn A. Rautenberg, Shu Kay Ng, et al. · Health and Quality of Life Outcomes · 6
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Seemingly Unrelated Regression Analysis of the Cost and Health-Related Quality of Life Outcomes of the REVAMP Randomized Clinical Trial
2023 · Tamlyn A. Rautenberg, Shu Kay Ng, et al. · Value in Health Regional Issues · 4
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Point-of-care urine tenofovir testing to predict HIV drug resistance among individuals with virologic failure
2023 · Suzanne M. McCluskey, Katya Govender, et al. · AIDS · 20
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Adherence, resistance, and viral suppression on dolutegravir in sub-Saharan Africa: implications for the TLD era
2021 · Suzanne M. McCluskey, Toby Pepperrell, et al. · AIDS · 65
Who’s slipping through the cracks? A comprehensive individual, clinical and health system characterization of people with virological failure on first‐line HIV treatment in Uganda and South Africa
2021 · Zahra Reynolds, Suzanne M. McCluskey, et al. · HIV Medicine · 8
Resistance Testing for Management of HIV Virologic Failure in Sub-Saharan Africa
2021 · Mark J. Siedner, Mahomed-Yunus S. Moosa, et al. · Annals of Internal Medicine · 22
CD4+ T-Cell Count at Antiretroviral Therapy Initiation in the “Treat-All” Era in Rural South Africa: An Interrupted Time Series Analysis
2021 · H Manisha Yapa, Hae-Young Kim, et al. · Clinical Infectious Diseases · 20
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A nurse-led intervention to improve management of virological failure in public sector HIV clinics in Durban, South Africa: A pre- and post-implementation evaluation
2021 · H Sunpath, S Pillay, et al. · South African Medical Journal · 7
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Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
2020 · Mark J. Siedner, Michelle A. Moorhouse, et al. · Nature Communications · 82
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The COVID-19 pandemic as a catalyst for differentiated care models to end the HIV epidemic in the United States: applying lessons from high-burden settings
2020 · Lauren F. Collins, Jonathan A. Colasanti, et al. · AIDS · 22
High Baseline Viremia: An Achilles Heel for Integrase Inhibitor–Based Antiretroviral Therapy?
2020 · Suzanne M McCluskey, Vincent C Marconi · Clinical Infectious Diseases
Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: an interrupted time series analysis
2020 · Mark J. Siedner, John D. Kraemer, et al. · BMJ Open · 200
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Learning from People with HIV: Their Insights are Critical to Our Response to the Intersecting COVID-19 and HIV Pandemics in Africa
2020 · Christine Aristide, Samson Okello, et al. · AIDS and Behavior · 11
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Protocol: Leveraging a demographic and health surveillance system for Covid-19 Surveillance in rural KwaZulu-Natal
2020 · Mark J. Siedner, Guy Harling, et al. · Wellcome Open Research · 20
Desperate Times Call for Temperate Measures: Practicing Infectious Diseases During a Novel Pandemic
2020 · Mark J Siedner, Rajesh T Gandhi, et al. · The Journal of Infectious Diseases · 5
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Does antiretroviral therapy use affect the accuracy of HIV rapid diagnostic assays? Experience from a demographic health and surveillance site in rural South Africa
2020 · Mark J. Siedner, Kathy Baisley, et al. · Diagnostic Microbiology and Infectious Disease · 3
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Prevention of cardiovascular disease among people living with HIV in sub-Saharan Africa
2020 · Samson Okello, Abdallah Amir, et al. · Progress in Cardiovascular Diseases · 49
Comparative analyses of published cost effectiveness models highlight critical considerations which are useful to inform development of new models
2019 · T. A. Rautenberg, G. George, et al. · Journal of Medical Economics · 2
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Findings from home‐based HIV testing and facilitated linkage after scale‐up of test and treat in rural South Africa: young people still missing
2019 · KJ Baisley, J Seeley, et al. · HIV Medicine · 43
Management of Virologic Failure and HIV Drug Resistance
2019 · Suzanne M. McCluskey, Mark J. Siedner, et al. · Infectious Disease Clinics of North America · 87
Targeting the third ‘90’: introducing the viral load champion
2018 · H. Sunpath, T. J. Hatlen, et al. · Public Health Action · 40
The REVAMP trial to evaluate HIV resistance testing in sub-Saharan Africa: a case study in clinical trial design in resource limited settings to optimize effectiveness and cost effectiveness estimates
2017 · Mark J. Siedner, Mwebesa B. Bwana, et al. · HIV Clinical Trials · 22
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