Award

Unlocking the structure, mechanism and cellular assembly of key multiprotein complexes in human gene transcription.

Funder: Wellcome Trust

Amount: £2,232,000

Funding type: grant

Funder scheme: Molecular Basis of Cell Function

Start date: 2015-05-01

End date: 2022-10-01

Investigator: Imre Berger

Institution: University of Bristol

Funded outputs count: 15

Funder award ID: 106115

OpenAlex ID: G7659908048

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

2024 · A Sofia F Oliveira, Fiona L Kearns, et al. · eLife · 7

Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD

2023 · S Basu, O Shukron, et al. · Nature Structural & Molecular Biology · 44

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The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron

2022 · Christine Toelzer, Kapil Gupta, et al. · Science Advances · 48

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Development and evaluation of low-volume tests to detect and characterize antibodies to SARS-CoV-2

2022 · Alice Halliday, Anna E Long, et al. · Frontiers in Immunology · 8

Bottom-up assembly of viral replication cycles

2022 · Oskar Staufer, Gösta Gantner, et al. · Nature Communications · 13

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Molecular dynamics of spike variants in the locked conformation: RBD interfaces, fatty acid binding and furin cleavage sites

2022 · Deborah K. Shoemark, A. Sofia F. Oliveira, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 7

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Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein

2022 · Oskar Staufer, Kapil Gupta, et al. · Nature Communications · 35

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Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2

2022 · Kapil Gupta, Christine Toelzer, et al. · Nature Communications · 36

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The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour

2021 · A. Sofia F. Oliveira, Deborah K. Shoemark, et al. · Computational and Structural Biotechnology Journal · 37

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TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage

2020 · Changwei Yu, Nevena Cvetesic, et al. · Nature Communications · 53

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Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

2020 · Christine Toelzer, Kapil Gupta, et al. · Science · 419

DNA origami-based single-molecule force spectroscopy elucidates RNA Polymerase III pre-initiation complex stability

2020 · Kevin Kramm, Tim Schröder, et al. · Nature Communications · 50

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Sequential Digestion with Trypsin and Elastase in Cross-Linking Mass Spectrometry

2019 · Therese Dau, Kapil Gupta, et al. · Analytical Chemistry · 40

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Homozygous TAF8 mutation in a patient with intellectual disability results in undetectable TAF8 protein, but preserved RNA polymerase II transcription

2018 · Farrah El-Saafin, Cynthia Curry, et al. · Human Molecular Genetics · 24

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