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Isotope Effects Cytochrome P 450 Catalyzed Oxidations

Funding type: research
Funder scheme: R01
Start date: 1986-07-01
End date: 1996-08-31
Investigator: WILLIAM F TRAGER
Institution: UNIVERSITY OF WASHINGTON
Funded outputs count: 14
Funder award ID: R01GM036922
OpenAlex ID: G1895402402
Intramolecular Isotope Effects for Benzylic Hydroxylation of Isomeric Xylenes and 4,4‘-Dimethylbiphenyl by Cytochrome P450: Relationship between Distance of Methyl Groups and Masking of the Intrinsic Isotope Effect
1997 · Krishna R. Iyer, Jeffrey P. Jones, et al. · Biochemistry · 43
Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450.
1996 · J F Darbyshire, K R Iyer, et al. · Drug Metabolism and Disposition · 25
Stereoselectivity and isotope effects associated with cytochrome P450-catalyzed oxidation of (S)-nicotine. The possibility of initial hydrogen atom abstraction in the formation of the delta 1', 5-nicotinium ion.
1995 · T J Carlson, J P Jones, et al. · Drug Metabolism and Disposition · 19
Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
1993 · Kent L. Kunze, William F. Trager · Chemical Research in Toxicology · 217
Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions
1993 · Kenneth R. Korzekwa, William F. Trager, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 34
Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase
1991 · Kenneth R. Korzekwa, William F. Trager, et al. · Biochemistry · 34
Isotope effect studies on the mechanism of the cytochrome P-450IIA1-catalyzed formation of delta 6-testosterone from testosterone.
1990 · K R Korzekwa, W F Trager, et al. · Drug Metabolism and Disposition · 43
Studies on the cytochrome P-450 catalyzed ring .alpha.-carbon oxidation of the nigrostriatal toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
1990 · Susanne Ottoboni, Timothy J. Carlson, et al. · Chemical Research in Toxicology · 23
Intrinsic isotope effects suggest that the reaction coordinate symmetry for the cytochrome P-450-catalyzed hydroxylation of octane is isozyme independent
1990 · Jeffrey P. Jones, Allan E. Rettie, et al. · Journal of Medicinal Chemistry · 36
The use of Brauman's least squares approach for the quantification of deuterated chlorophenols
1990 · Kenneth Korzekwa, William N. Howald, et al. · Journal of Mass Spectrometry · 25
Isotopically labeled chlorobenzenes as probes for the mechanism of cytochrome P-450 catalyzed aromatic hydroxylation
1989 · Kenneth R. Korzekwa, David C. Swinney, et al. · Biochemistry · 97
Theory for the observed isotope effects from enzymic systems that form multiple products via branched reaction pathways: cytochrome P-450
1989 · Kenneth R. Korzekwa, William F. Trager, et al. · Biochemistry · 56
Stereochemistry of Cytochrome P-450 Reactions
1989 · William F. Trager · Drug Metabolism Reviews · 20
Prochiral selectivity and intramolecular isotope effects in the cytochrome P-450 catalyzed .omega.-hydroxylation of cumene
1986 · Katsumi Sugiyama, William F. Trager · Biochemistry · 27
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