Rad50: Roles in chromo. stab. and prev. of malignancy
Description: PUBLIC HEALTH RELEVANCE: Genome instability is a hallmark of cancer, and defects in the DNA damage response, which is required for the maintenance of genome stability are associated with cancer as well as human syndromes associated with reproductive, developmental and neurological defects. We address the functions of a central DNA damage response component, the Mre11 complex. This complex has been implicated in human chromosome instability syndromes associated with increased risk of malignancy, and has also found to be defective in sporadic cancers. The experiments described in this application examine the Mre11 complex and have the potential to provide insights regarding the mechanisms underlying cancer predisposition, as well as those that may present suitable targets for interdiction in therapeutic settings.
Funding type: research
Funder scheme: R01
Start date: 1998-01-01
End date: 2020-12-31
Investigator: JOHN HJ PETRINI
Institution: SLOAN-KETTERING INST CAN RESEARCH
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 56
Funder award ID: R01GM056888
OpenAlex ID: G7745870410