Exercise, Diabetes, & Coronary Smooth Muscle Ca2+
Description: Our studies involve highly clinically relevant coronary artery disease in the Ossabaw miniature pig, which superbly mimics complex metabolic syndrome ("pre-diabetes") and type 2 diabetes in humans. Thus, our findings will catalyze the translation of novel therapeutic interventions to humans, including bioengineered devices, drug-eluting stents (scaffold to open occluded artery), and systemic drug therapy. Drugs currently approved for humans are very likely to find new uses in treatment of coronary disease. We are uniquely positioned to benefit the prevention and regression of coronary disease, which will improve health in the U.S.
Funding type: research
Funder scheme: R01
Start date: 1999-04-01
End date: 2015-01-31
Investigator: MICHAEL STUREK
Institution: INDIANA UNIVERSITY INDIANAPOLIS
Funded outputs count: 76
Funder award ID: R01HL062552
OpenAlex ID: G776717618