Award

Role of brown fat-derived specialized pro-resolving lipid mediators in inflammation and metabolism

Description: Project Narrative Obesity and diabetes are the two most prominent health burdens in the United States. The proposed research aims to understand the mechanisms of action of brown fat-derived lipid mediators that exert anti- inflammatory and anti-obesity effects. The success of the proposed studies will improve our knowledge of resolution of inflammation and provide promising therapeutic approaches for the treatment and prevention of obesity and diabetes.
Funding type: research
Funder scheme: R01
Start date: 2020-04-01
End date: 2025-01-31
Investigator: MATTHEW R SPITE
Institution: JOSLIN DIABETES CENTER
Subfield: Physiology
Field: Medicine
Funded outputs count: 22
Funder award ID: R01DK122808
OpenAlex ID: G7828397516
2026 · Carolyn Chlebek, Valerie Bussberg, et al. · Frontiers in Endocrinology
2025 · Ling Xiao, Dario F. De Jesus, et al. · Nature Communications · 20
2024 · Erin E. Mauney, Marsha C. Wibowo, et al. · Trends in Endocrinology and Metabolism · 16
2024 · Chih-Hao Wang, Tadataka Tsuji, et al. · Nature Communications · 10
2024 · Jonathan M. Dreyfuss, Vera Djordjilović, et al. · Communications Biology · 11
2024 · Tadataka Tsuji, Vladimir Tolstikov, et al. · Nature Communications · 16
2024 · Mary E Walker, Sean D Kodani, et al. · The Journal of Clinical Endocrinology & Metabolism · 7
2023 · Farnaz Shamsi, Rongbin Zheng, et al. · Communications Biology · 20
2023 · Tadataka Tsuji, Yu-Hua Tseng · Current Opinion in Genetics & Development · 16
2023 · Matthew Spite, Gabrielle Fredman · Advances in pharmacology · 13
2022 · Satoru Sugimoto, Hebe Agustina Mena, et al. · Nature Metabolism · 106
2022 · Sean D. Kodani, Valerie Bussberg, et al. · Methods in molecular biology · 3
2021 · Hebe Agustina Mena, Matthew Spite · Journal of Clinical Investigation · 8
2021 · Farnaz Shamsi, Chih-Hao Wang, et al. · Nature Reviews Endocrinology · 175
2021 · Cheryl Cero, Hannah J. Lea, et al. · JCI Insight · 237
2021 · Anthony R. Angueira, Alexander P. Sakers, et al. · Nature Metabolism · 142
2021 · Farnaz Shamsi, Yu-Hua Tseng, et al. · Cell Metabolism · 10
2020 · Luiz O. Leiria, Yu-Hua Tseng · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 84
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