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Genetic and Proteomic Analysis of Epstein-Barr Virus LMP1 Activation of NF-kB

Description: Relevance Persistent Epstein Barr virus infection is an important cause of certain lymphoma and throat cancers. This project will better define how EBV subverts cellular machinery to drive cancerous growth of infected cells. Ultimately, it is hoped that knowledge gained from these studies may enable the development of chemotherapies that specifically block EBV function.
Funding type: career_development
Funder scheme: K08
Start date: 2010-07-01
End date: 2015-09-30
Investigator: BENJAMIN ELISON GEWURZ
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Oncology
Field: Medicine
Funded outputs count: 15
Funder award ID: K08CA140780
OpenAlex ID: G3008225667
CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors
2017 · Yijie Ma, Michael J. Walsh, et al. · Cell Host & Microbe · 137
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A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells
2017 · Ina Ersing, Luis Nobre, et al. · Cell Reports · 97
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The NF-κB subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma
2015 · J E Hunter, J A Butterworth, et al. · Oncogene · 35
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Evasion of affinity-based selection in germinal centers by Epstein–Barr virus LMP2A
2015 · Takeharu Minamitani, Teruhito Yasui, et al. · Proceedings of the National Academy of Sciences · 53
TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation
2015 · Hannah Greenfeld, Kaoru Takasaki, et al. · PLoS Pathogens · 76
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Epstein-Barr Virus Oncoprotein Super-enhancers Control B Cell Growth
2015 · Hufeng Zhou, Stefanie C.S. Schmidt, et al. · Cell Host & Microbe · 171
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Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
2014 · Alessio Iannetti, Adeline C. Ledoux, et al. · PLoS Genetics · 105
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The NF-κB Genomic Landscape in Lymphoblastoid B Cells
2014 · Bo Zhao, Luis A. Barrera, et al. · Cell Reports · 157
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Remodeling of the Intestinal Brush Border Underlies Adhesion and Virulence of an Enteric Pathogen
2014 · Xiaohui Zhou, Ramiro H. Massol, et al. · mBio · 37
NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1
2013 · Ina Ersing, Katharina Bernhardt, et al. · Viruses · 80
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A Vibrio parahaemolyticus T3SS Effector Mediates Pathogenesis by Independently Enabling Intestinal Colonization and Inhibiting TAK1 Activation
2013 · Xiaohui Zhou, Benjamin E. Gewurz, et al. · Cell Reports · 95
Genome-wide siRNA screen for mediators of NF-κB activation
2012 · Benjamin E. Gewurz, Fadi Towfic, et al. · Proceedings of the National Academy of Sciences · 106
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Canonical NF-κB Activation Is Essential for Epstein-Barr Virus Latent Membrane Protein 1 TES2/CTAR2 Gene Regulation
2011 · Benjamin E. Gewurz, Jessica C. Mar, et al. · Journal of Virology · 47
La utilización del precio como variable comercial por parte del minorista
1993 · Ángel Fernández Nogales · Información Comercial Española, ICE: Revista de economía · 3
Information technology and home-based services: improving the usability of teleshopping
1987 · John Long · The MIT Press eBooks · 1
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