Award

KLF4-Dependent Regulation of SMC Differentiation and Phenotypic Switching

Description: Project Narrative Abnormal control of the differentiated state (i.e. cell specific properties) of vascular smooth muscle cells (SMC) is known to play a critical role in a number of major diseases including atherosclerosis, asthma, hypertension, and tumor metastasis. Studies in this proposal will provide novel insights into mechanisms that control SMC differentiation in development and disease and may lead to new and more effective therapies.

Funder: National Heart, Lung, and Blood Institute

Funding type: research

Funder scheme: R01

Start date: 2010-01-12

End date: 2013-11-30

Investigator: GARY K OWENS

Institution: UNIVERSITY OF VIRGINIA

Topic: Kruppel-like factors research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 18

Funder award ID: R01HL098538

OpenAlex ID: G799071978

Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction

2022 · Junchul Shin, Svyatoslav Tkachenko, et al. · Cardiovascular Research · 37

Novel Autoimmune IgM Antibody Attenuates Atherosclerosis in IgM Deficient Low-Fat Diet–Fed, but Not Western Diet–Fed Apoe –/– Mice

2019 · Olga A. Cherepanova, Prasad Srikakulapu, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 25

Cigarette Smoke Initiates Oxidative Stress-Induced Cellular Phenotypic Modulation Leading to Cerebral Aneurysm Pathogenesis

2018 · Robert M. Starke, John W. Thompson, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 88

Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions

2017 · Brittany G. Durgin, Olga A. Cherepanova, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 42

Shifting the Focus of Preclinical, Murine Atherosclerosis Studies From Prevention to Late-Stage Intervention

2017 · Richard A. Baylis, Delphine Gomez, et al. · Circulation Research · 21

Reconciling Smooth Muscle Cell Oligoclonality and Proliferative Capacity in Experimental Atherosclerosis

2016 · Delphine Gomez, Gary K. Owens · Circulation Research · 28

Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective

2016 · Olga A Cherepanova, Delphine Gomez, et al. · Nature Medicine · 221

Vascular Smooth Muscle Cells in Atherosclerosis

2016 · Martin R. Bennett, Sanjay Sinha, et al. · Circulation Research · 2,179

Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory

2015 · Delphine Gomez, Pamela Swiatlowska, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 123

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

2015 · Laura S Shankman, Delphine Gomez, et al. · Nature Medicine · 1,214

Critical role of TNF-α in cerebral aneurysm formation and progression to rupture

2014 · Robert M Starke, Nohra Chalouhi, et al. · Journal of Neuroinflammation · 136

Cigarette Smoke Modulates Vascular Smooth Muscle Phenotype: Implications for Carotid and Cerebrovascular Disease

2013 · Robert M. Starke, Muhammad S. Ali, et al. · PLoS ONE · 54

TNF-α Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Pathology

2013 · Muhammad S Ali, Robert M Starke, et al. · Journal of Cerebral Blood Flow & Metabolism · 161

Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels

2013 · Meera Murgai, James Thomas, et al. · Retrovirology · 3

Detection of histone modifications at specific gene loci in single cells in histological sections

2013 · Delphine Gomez, Laura S Shankman, et al. · Nature Methods · 253

Cooperative Binding of KLF4, pELK-1, and HDAC2 to a G/C Repressor Element in the SM22α Promoter Mediates Transcriptional Silencing During SMC Phenotypic Switching In Vivo

2012 · Morgan Salmon, Delphine Gomez, et al. · Circulation Research · 160

Smooth muscle cell phenotypic switching in atherosclerosis

2012 · D. Gomez, G. K. Owens · Cardiovascular Research · 866

Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes

2011 · Mark H. Hoofnagle, Ronald L. Neppl, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 44