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Ab5 Toxins Nasal Adjuvant Target the Olfactory Bulbs/CNS

Funding type: research
Funder scheme: R01
Start date: 2001-04-01
End date: 2006-03-31
Investigator: KOHTARO FUJIHASHI
Institution: UNIVERSITY OF ALABAMA AT BIRMINGHAM
Funded outputs count: 25
Funder award ID: R01DC004976
OpenAlex ID: G7990939529
A single intranasal immunization with inactivated influenza virus and α-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system
2007 · Hyun-Jun Youn, Sung-Youl Ko, et al. · Vaccine · 95
Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice
2007 · Romy Fischer, Daniel Tomé, et al. · Biochemical and Biophysical Research Communications · 24
Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Aβ1‐6 upregulates IL‐10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease
2007 · Hong‐Duck Kim, Kazuki Tahara, et al. · The Journal of Gene Medicine · 44
Mucosal Vaccine Targeting Improves Onset of Mucosal and Systemic Immunity to Botulinum Neurotoxin A
2006 · Massimo Maddaloni, Herman F Staats, et al. · The Journal of Immunology · 30
A Second Generation of Double Mutant Cholera Toxin Adjuvants: Enhanced Immunity without Intracellular Trafficking
2006 · Yukari Hagiwara, Yuki I Kawamura, et al. · The Journal of Immunology · 42
Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens
2006 · Alexandra Duverger, Raymond J Jackson, et al. · The Journal of Immunology · 70
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Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy
2005 · Romy Fischer, Jerry R. McGhee, et al. · American Journal Of Pathology · 53
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Enterotoxin-Based Mucosal Adjuvants Alter Antigen Trafficking and Induce Inflammatory Responses in the Nasal Tract
2005 · Frederik W. van Ginkel, Raymond J. Jackson, et al. · Infection and Immunity · 83
A Novel Neurotoxoid Vaccine Prevents Mucosal Botulism
2005 · Ryoki Kobayashi, Tomoko Kohda, et al. · The Journal of Immunology · 36
CD4+CD45RBHi Interleukin-4 Defective T Cells Elicit Antral Gastritis and Duodenitis
2004 · Taeko Dohi, Kohtaro Fujihashi, et al. · American Journal Of Pathology · 16
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Nasal Flt3 Ligand cDNA Elicits CD11c+CD8+ Dendritic Cells for Enhanced Mucosal Immunity
2004 · Kosuke Kataoka, Jerry R McGhee, et al. · The Journal of Immunology · 72
Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection
2003 · Frederik W. van Ginkel, Jerry R. McGhee, et al. · Proceedings of the National Academy of Sciences · 116
Cholera toxin activates dendritic cells through dependence on GM1‐ganglioside which is mediated by NF‐κB translocation
2003 · Yuki I. Kawamura, Rei Kawashima, et al. · European Journal of Immunology · 84
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IFN-γ-Inducible Chemokines Enhance Adaptive Immunity and Colitis
2003 · Udai P. Singh, Shailesh Singh, et al. · Journal of Interferon & Cytokine Research · 61
Immunizations with Pneumococcal Surface Protein A and Pneumolysin Are Protective against Pneumonia in a Murine Model of Pulmonary Infection withStreptococcus pneumoniae
2003 · David E. Briles, Susan K. Hollingshead, et al. · The Journal of Infectious Diseases · 234
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Effective Mucosal Immunity to Anthrax: Neutralizing Antibodies and Th Cell Responses Following Nasal Immunization with Protective Antigen
2003 · Prosper N Boyaka, Angela Tafaro, et al. · The Journal of Immunology · 134
T helper type-2 cells induce ileal villus atrophy, goblet cell metaplasia, and wasting disease in T cell–deficient mice
2003 · Taeko Dohi, Kohtaro Fujihashi, et al. · Gastroenterology · 50
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Protective Mucosal Immunity in Aging Is Associated with Functional CD4+ T Cells in Nasopharyngeal-Associated Lymphoreticular Tissue
2003 · Yukari Hagiwara, Jerry R McGhee, et al. · The Journal of Immunology · 82
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Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions
2003 · H. Kato · International Immunology · 69
MIP-1α and MIP-1β differentially mediate mucosal and systemic adaptive immunity
2003 · James W. Lillard, Udai P. Singh, et al. · Blood · 97
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Chimeras of Labile Toxin One and Cholera Toxin Retain Mucosal Adjuvanticity and Direct Th Cell Subsets Via Their B Subunit
2003 · Prosper N Boyaka, Mari Ohmura, et al. · The Journal of Immunology · 52
A Nontoxic Chimeric Enterotoxin Adjuvant Induces Protective Immunity in Both Mucosal and Systemic Compartments with Reduced IgE Antibodies
2002 · Mi‐Na Kweon, Masafumi Yamamoto, et al. · The Journal of Infectious Diseases · 66
A dilemma for mucosal vaccination: efficacy versus toxicity using enterotoxin-based adjuvants
2002 · Kohtaro Fujihashi, Toshiya Koga, et al. · Vaccine · 175
Highly purified mutant E112K of cholera toxin elicits protective lung mucosal immunity to diphtheria toxin
2001 · Mari Ohmura, Masafumi Yamamoto, et al. · Vaccine · 17
The Pulmonary Environment Promotes Th2 Cell Responses After Nasal-Pulmonary Immunization with Antigen Alone, but Th1 Responses Are Induced During Instances of Intense Immune Stimulation
2001 · Harlan P Jones, Lisa M Hodge, et al. · The Journal of Immunology · 64
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