Award

TMJ Disc Regeneration

Description: Project Narrative Epidemiologically, over 80 million people in the U.S. have symptoms of temporomandibular joint (TMJ) disorders, with roughly 60 million people exhibiting defects in the TMJ disc. Disc defects begin as focal thinning that eventually grows into large perforations, with the number of people suffering from disc perforation estimated at 9 million. This proposal's public health relevance is in its potential to use tissue-engineered implants to address morbidity caused by disc-thinning and perforation defects.
Funding type: research
Funder scheme: R01
Start date: 2004-07-01
End date: 2024-05-31
Investigator: KYRIACOS A ATHANASIOU
Institution: UNIVERSITY OF CALIFORNIA-IRVINE
Funded outputs count: 57
Funder award ID: R01DE015038
OpenAlex ID: G7990940335
2025 · Raul Ramos, Kim T. Pham, et al. · Science · 36
2023 · Ryan P. Donahue, Eston G. Kallins, et al. · Tissue Engineering Part A · 3
2022 · Benjamin J. Bielajew, Ryan P. Donahue, et al. · Biomaterials Research · 11
2022 · Benjamin J. Bielajew, Ryan P. Donahue, et al. · Acta Biomaterialia · 27
2021 · Benjamin J. Bielajew, Jerry C. Hu, et al. · Cartilage · 24
2021 · Ryan P. Donahue, Rachel C. Nordberg, et al. · Tissue Engineering Part A · 12
2021 · Nathan J. Castro, Greta Babakhanova, et al. · Trends in biotechnology · 16
2021 · Benjamin J. Bielajew, Ryan P. Donahue, et al. · Cell Reports Medicine · 42
2021 · Heenam Kwon, Wendy E Brown, et al. · Biofabrication · 20
2020 · Benjamin J. Bielajew, Jerry C. Hu, et al. · Nature Reviews Materials · 319
2019 · Ryan P. Donahue, Jerry C. Hu, et al. · Trends in Molecular Medicine · 39
2018 · Ryan P. Donahue, Erik A. Gonzalez-Leon, et al. · Journal of Biomechanical Engineering · 18
2018 · Natalia Vapniarsky, Le W. Huwe, et al. · Science Translational Medicine · 115
2017 · Le W. Huwe, Wendy E. Brown, et al. · Journal of Tissue Engineering and Regenerative Medicine · 52
2017 · Jennifer K. Lee, Le W. Huwe, et al. · Nature Materials · 96
2017 · Natalia Vapniarsky, Ashkan Aryaei, et al. · Tissue Engineering Part C Methods · 43
2017 · Derek D. Cissell, Jarrett M. Link, et al. · Tissue Engineering Part C Methods · 238
2014 · Grayson D. DuRaine, Wendy E. Brown, et al. · Annals of Biomedical Engineering · 155
2014 · Eleftherios A. Makris, Andreas H. Gomoll, et al. · Nature Reviews Rheumatology · 1,248
2013 · Meghan K. Murphy, Taylor E. Masters, et al. · Cell Transplantation · 25
2013 · Meghan K Murphy, Grayson D DuRaine, et al. · Arthritis Research & Therapy · 20
2013 · Jennifer K. Lee, Donald J. Responte, et al. · Critical Reviews in Biotechnology · 36
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