Award

HIV-1 evolution in the female genital tract and trafficking to the blood

Description: PUBLIC HEALTH RELEVANCE: We have observed that HIV populations may grow in the genital tract because cells with virus appear to proliferate, probably due to infections and traumas (e.g., sexual intercourse, tampons, etc.). If a significant fraction of genital tract HIV is derived from proliferation of infected cells, this phenomenon may present a major obstacle to curing HIV infection; unless novel approaches can be developed to eliminate HIV infection from the body.

Funder: National Institute of Allergy and Infectious Diseases

Funding type: research

Funder scheme: R01

Start date: 2011-01-21

End date: 2017-12-31

Investigator: LISA M FRENKEL

Institution: SEATTLE CHILDREN'S HOSPITAL

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

Funded outputs count: 11

Funder award ID: R01AI091550

OpenAlex ID: G79914761

Longitudinal cervicovaginal bacteriome and virome alterations associate with discordant shedding and ART duration in women living with HIV in Peru

2025 · Emily A. Kaelin, Caroline Mitchell, et al. · Nature Communications · 10

Genome sequences of human anelloviruses in the Lamedtorquevirus , Memtorquevirus , and Samektorquevirus genera identified from the female genital tract

2024 · Eric D. Do, Steven C. Holland, et al. · Microbiology Resource Announcements · 2

Genital Shedding of Human Immunodeficiency Virus Type-1 (HIV) When Antiretroviral Therapy Suppresses HIV Replication in the Plasma

2020 · Marta Bull, Caroline Mitchell, et al. · The Journal of Infectious Diseases · 12

Phylogenetic Analyses Comparing HIV Sequences from Plasma at Virologic Failure to Cervix Versus Blood Sequences from Antecedent Antiretroviral Therapy Suppression

2019 · Marta E. Bull, Jennifer L. McKernan, et al. · AIDS Research and Human Retroviruses · 3

Monotypic low-level HIV viremias during antiretroviral therapy are associated with disproportionate production of X4 virions and systemic immune activation

2018 · Marta E. Bull, Caroline Mitchell, et al. · AIDS · 18

Clonal Expansion of Human Immunodeficiency Virus–Infected Cells and Human Immunodeficiency Virus Persistence During Antiretroviral Therapy

2017 · James I. Mullins, Lisa M. Frenkel · The Journal of Infectious Diseases · 30

Biomarkers of inflammation in HIV-infected Peruvian men and women before and during suppressive antiretroviral therapy

2015 · Eduardo Ticona, Marta E. Bull, et al. · AIDS · 25

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection

2014 · Thor A. Wagner, Sherry McLaughlin, et al. · Science · 677

Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses but Genital Lineages Do Not Persist Over Time

2013 · Marta E. Bull, Laura M. Heath, et al. · The Journal of Infectious Diseases · 31

An Increasing Proportion of Monotypic HIV-1 DNA Sequences during Antiretroviral Treatment Suggests Proliferation of HIV-Infected Cells

2012 · Thor A. Wagner, Jen L. McKernan, et al. · Journal of Virology · 90

Transmitted HIV Resistance to First-Line Antiretroviral Therapy in Lima, Peru

2011 · Jaime Soria, Marta Bull, et al. · AIDS Research and Human Retroviruses · 18