Ultrasound Gene Therapy for Tendinopathy
Description: Chronic tendinopathy is a commonly seen disorder, especially in rehabilitation medicine, and is responsible for substantial morbidity and pain of victims. Although various treatments existed, their effects are sometimes inconsistent and frustrating. The main purpose of this proposed study is to develop a novel treatment method, i.e., gene therapy, aiming at curing this annoying disorder. Our basic approach was modified from the new treatment modality, the platelet‐rich plasma injection for tendinopathy. The main procedure includes the following steps, (1) get adequate venous blood from peripheral vessels,; (2) extract platelet rich plasma layer by spinning; (3) transfect therapeutic DNA, in the current proposal, TGF‐beta plasmid; (4) ultrasound gene transfection of therapeutic plasmids to the soft tissue between tendon and muscle, and hopefully, the transfected plasmids will exert their therapeutic effect on target tendons. We plan to use three years to develop the basic techniques necessary for future human trials, and probe the possible intracellular signal pathways of the proposed method.
Amount: TWD 3,294,000
Funding type: research
Funder scheme: 學術補助
Investigator: 陳文翔 (lead)
Institution: 國立臺灣大學醫學院復健科
Funded outputs count: 2
Funder award ID: MOST103-2314-B002-011-MY3
OpenAlex ID: G7991526754