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Role of Macrophage Migration Inhibitory Factor in Osteoclastogenesis

Description: PROJECT NARRATIVE: This current project will examine the mechanism by which MIF plays an important role in the osteoclastogenesis. By studying the mechanism how MIF affects bone cells in normal and pathologic conditions including arthritis, we hope to better understand the role that MIF plays in bone physiology. It is anticipated that this knowledge will identify new target for interventions, which can be used to create therapies to reverse bone loss, improve bone quality and prevent the morbidities that are associated with the development of osteoporosis and other metabolic bone diseases.

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding type: research

Funder scheme: R01

Start date: 2009-05-15

End date: 2015-04-30

Investigator: SUN-KYEONG LEE

Institution: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

Topic: Macrophage Migration Inhibitory Factor

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Funded outputs count: 9

Funder award ID: R01AR055143

OpenAlex ID: G7991613425

Contradictory Role of CD97 in Basal and Tumor Necrosis Factor–Induced Osteoclastogenesis In Vivo

2015 · Hee Yeon Won, Se Hwan Mun, et al. · Arthritis & Rheumatology · 15

Pathway Analysis of MicroRNA Expression Profile during Murine Osteoclastogenesis

2014 · Tiziana Franceschetti, Neha S. Dole, et al. · PLoS ONE · 42

Macrophage Migration Inhibitory Factor Down‐Regulates the RANKL–RANK Signaling Pathway by Activating Lyn Tyrosine Kinase in Mouse Models

2014 · Se Hwan Mun, Dongmyung Oh, et al. · Arthritis & Rheumatology · 20

miR-29 Promotes Murine Osteoclastogenesis by Regulating Osteoclast Commitment and Migration

2013 · Tiziana Franceschetti, Catherine B. Kessler, et al. · Journal of Biological Chemistry · 127

Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels

2012 · Sandra Jastrzebski, Judith Kalinowski, et al. · Journal of Bone and Mineral Research · 52

Deletion of CD74, a putative MIF receptor, in mice enhances osteoclastogenesis and decreases bone mass

2012 · Se Hwan Mun, Hee Yeon Won, et al. · Journal of Bone and Mineral Research · 55

Osteoblast-specific overexpression of human interleukin-7 rescues the bone mass phenotype of interleukin-7–deficient female mice

2012 · Hector L Aguila, Se Hwan Mun, et al. · Journal of Bone and Mineral Research · 53

Parathyroid hormone regulates the distribution and osteoclastogenic potential of hematopoietic progenitors in the bone marrow

2010 · Christian E Jacome-Galarza, Sun-Kyeong Lee, et al. · Journal of Bone and Mineral Research · 36

Macrophage migration inhibitory factor inhibits osteoclastogenesis

2009 · Claire Jacquin, Boguslawa Koczon-Jaremko, et al. · Bone · 46