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Risk prediction of atrial fibrillation: clinical, biological and genetic markers

Description: 7. Project Narrative. Atrial fibrillation, a highly prevalent, irregular heart rhythm, increases the risk of stroke and death, yet how to predict and prevent atrial fibrillation in the individual is not well understood. Investigators from five community studies have formed a collaboration to create a model to predict the development of atrial fibrillation and to determine whether biological or genetic markers help to further classify the risk of atrial fibrillation beyond standard clinical factors. The investigators will develop new methods and predictive tools that will inform clinical decisions and target interventions aimed at the prevention of atrial fibrillation.
Funding type: research
Funder scheme: RC1
Start date: 2009-09-30
End date: 2012-07-31
Investigator: ALVARO ALONSO
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Field: Medicine
Funded outputs count: 82
Funder award ID: RC1HL101056
OpenAlex ID: G799175419
B-type natriuretic peptide and C-reactive protein in the prediction of atrial fibrillation risk: the CHARGE-AF Consortium of community-based cohort studies
2020 · Stepas, Katherine A., Kronmal, Richard A., et al. · Carolina Digital Repository (University of North Carolina at Chapel Hill)
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Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study
2020 · Nicklas Vinter, Qiuxi Huang, et al. · BMJ · 82
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Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes
2018 · Sara L. Pulit, Lu-Chen Weng, et al. · Neurology Genetics · 51
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Genetic Predisposition, Clinical Risk Factor Burden, and Lifetime Risk of Atrial Fibrillation
2017 · Lu-Chen Weng, Sarah R. Preis, et al. · Circulation · 274
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium
2017 · Lu-Chen Weng, Kathryn L. Lunetta, et al. · Scientific Reports · 19
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Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study
2017 · Michelle T. Long, Xiaoyan Yin, et al. · Journal of the American Heart Association · 55
Genetic Obesity and the Risk of Atrial Fibrillation
2016 · Neal A. Chatterjee, Franco Giulianini, et al. · Circulation · 133
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Serum brain-derived neurotrophic factor and risk of atrial fibrillation
2016 · Faisal Rahman, Jayandra J. Himali, et al. · American Heart Journal · 15
Evaluation of a Prediction Model for the Development of Atrial Fibrillation in a Repository of Electronic Medical Records
2016 · Matthew J. Kolek, Amy J. Graves, et al. · JAMA Cardiology · 57
Relation of Pericardial Fat, Intrathoracic Fat, and Abdominal Visceral Fat With Incident Atrial Fibrillation (from the Framingham Heart Study)
2016 · Jane J. Lee, Xiaoyan Yin, et al. · The American Journal of Cardiology · 36
Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)
2016 · Darae Ko, Eric M. Riles, et al. · The American Journal of Cardiology · 35
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Trajectories of Risk Factors and Risk of New-Onset Atrial Fibrillation in the Framingham Heart Study
2016 · Faisal Rahman, Xiaoyan Yin, et al. · Hypertension · 68
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Association of Atrial Fibrillation and Cancer
2016 · Faisal Rahman, Darae Ko, et al. · JAMA Cardiology · 51
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A comparison of the CHARGE–AF and the CHA2DS2-VASc risk scores for prediction of atrial fibrillation in the Framingham Heart Study
2016 · Ingrid E. Christophersen, Xiaoyan Yin, et al. · American Heart Journal · 103
Atrial Fibrillation and Declining Physical Performance in Older Adults
2016 · Jared W. Magnani, Na Wang, et al. · Circulation Arrhythmia and Electrophysiology · 70
Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study)
2016 · Eun-Jeong Kim, Xiaoyan Yin, et al. · American Heart Journal · 47
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Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
2016 · Darae Ko, Faisal Rahman, et al. · Nature Reviews Cardiology · 353
Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium
2016 · Faye L. Norby, Samuel Adamsson Eryd, et al. · PLoS ONE · 18
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Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation
2016 · Renate B. Schnabel, Renke Maas, et al. · American Heart Journal · 14
50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study
2015 · Renate B Schnabel, Xiaoyan Yin, et al. · The Lancet · 1,746
Contraindications to Anticoagulation Therapy and Eligibility for Novel Anticoagulants in Older Patients with Atrial Fibrillation
2015 · Benjamin A. Steinberg, Melissa A. Greiner, et al. · Cardiovascular Therapeutics · 89
Long-Term Outcomes of Secondary Atrial Fibrillation in the Community
2015 · Steven A. Lubitz, Xiaoyan Yin, et al. · Circulation · 238
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Geographic variation in the use of catheter ablation for atrial fibrillation among Medicare beneficiaries
2015 · Moritz F. Sinner, Jonathan P. Piccini, et al. · American Heart Journal · 15
Blood Lipids and the Incidence of Atrial Fibrillation: The Multi‐Ethnic Study of Atherosclerosis and the Framingham Heart Study
2014 · Alvaro Alonso, Xiaoyan Yin, et al. · Journal of the American Heart Association · 196
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A Common SCN5A Variant Is Associated with PR Interval and Atrial Fibrillation Among African Americans
2014 · LEONARD ILKHANOFF, DAN E. ARKING, et al. · Journal of Cardiovascular Electrophysiology · 23
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