Inhibiting axon degeneration in a mouse model of acute brain injury through deletion of Sarm1
Description: PUBLIC HEALTH RELEVANCE: Traumatic brain injury (TBI) is a leading cause of disability with an estimated 5 million Americans living with long-term disability related to TBI and associated annual direct and indirect costs in excess of $70 billion. Traumatic degeneration of axons, the functional connection between neurons in the brain, is a hallmark of TBI and key cause of post-traumatic functional deficits. This study will investigate whether blocking of the first discovered gene to drive a genetic axon death program (Sarm1) in mice reduces post-TBI axon degeneration and whether this translates to improved behavioral outcome.
Funding type: career_development
Funder scheme: K08
Start date: 2016-04-01
End date: 2021-02-28
Investigator: NILS HENNINGER
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Funded outputs count: 59
Funder award ID: K08NS091499
OpenAlex ID: G7992372027