Defining the contribution of ATR to MC1R-enhanced DNA repair in melanocytes
Description: PUBLIC HEALTH RELEVANCEL: Melanoma, the deadliest form of skin cancer, affects nearly 80,000 individuals in the United States each year. The proposed study focuses on the role of a receptor known as the melanocortin 1 receptor (MC1R) that is important in normal pigmentation. Inherited defects in MC1R affect millions of Americans who are at elevated risk from ultraviolet light damage and mutations and as a result have a high risk for melanoma. By discovering how MC1R protects against melanoma formation, our goal is to develop therapies to prevent melanoma.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R01
Start date: 2010-07-01
End date: 2022-03-31
Investigator: JOHN A D'ORAZIO
Institution: UNIVERSITY OF KENTUCKY
Subfield: Cell Biology
Domain: Life Sciences
Funded outputs count: 28
Funder award ID: R01CA131075
OpenAlex ID: G7992602378