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Liver kinase B1 in angiogenesis

Description: Project Narrative The overall goal of this project is to define the molecular mechanism by which LKB1 enhances NRP-1 degradation and suppresses transcriptional expression of VEGF thereby leading to aberrant signaling within the vascular niche resulting in a reduction in tumor growth and ischemic angiogenesis. .

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2016-12-07

End date: 2021-11-30

Investigator: MING-HUI ZOU

Institution: GEORGIA STATE UNIVERSITY

Funded outputs count: 42

Funder award ID: R01CA213022

OpenAlex ID: G7992968323

Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation

2022 · Qiang Zhao, Young-Min Han, et al. · Nature Communications · 20

AMP-activated protein kinase alpha1 promotes tumor development via FOXP3 elevation in tumor-infiltrating Treg cells

2021 · Junqing An, Ye Ding, et al. · iScience · 21

Activation of AMPKα1 is essential for regulatory T cell function and autoimmune liver disease prevention

2021 · Huaiping Zhu, Zhaoyu Liu, et al. · Cellular and Molecular Immunology · 37

AMPK and Pulmonary Hypertension: Crossroads Between Vasoconstriction and Vascular Remodeling

2021 · Qiang Zhao, Ping Song, et al. · Frontiers in Cell and Developmental Biology · 36

Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer

2021 · Donghong Zhang, Jinfeng Ning, et al. · Cell Death and Disease · 65

Deletion of Ulk1 inhibits neointima formation by enhancing KAT2A/GCN5-mediated acetylation of TUBA/α-tubulin in vivo

2021 · Changhan Ouyang, Jian Li, et al. · Autophagy · 32

FUNDC1-dependent mitochondria-associated endoplasmic reticulum membranes are involved in angiogenesis and neoangiogenesis

2021 · Cheng Wang, Xiaoyan Dai, et al. · Nature Communications · 128

Lkb1 is a master regulator of VSMC fate and function in mice

2020 · Zhaohua Cai, Ping Song, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1

BRD4 inhibition by JQ1 prevents high-fat diet-induced diabetic cardiomyopathy by activating PINK1/Parkin-mediated mitophagy in vivo

2020 · Jing Mu, Donghong Zhang, et al. · Journal of Molecular and Cellular Cardiology · 102

Loss of AMPKalpha1 Triggers Centrosome Amplification via PLK4 Upregulation in Mouse Embryonic Fibroblasts

2020 · Qiang Zhao, Kathleen A Coughlan, et al. · International Journal of Molecular Sciences · 4

Targeting senescent cells to attenuate cardiovascular disease progression

2020 · Ping Song, Qiang Zhao, et al. · Ageing Research Reviews · 76

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

2020 · Ping Song, Junqing An, et al. · Cells · 198

Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation

2019 · Changhan Ouyang, Jing Mu, et al. · Autophagy · 33

Cardiomyocyte‐Specific Snrk Prevents Inflammation in the Heart

2019 · Karthikeyan Thirugnanam, Stephanie M. Cossette, et al. · Journal of the American Heart Association · 17

Peroxynitrite-Mediated SIRT (Sirtuin)-1 Inactivation Contributes to Nicotine-Induced Arterial Stiffness in Mice

2019 · Ye Ding, Yi Han, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 37

Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-κB/p65 regulatory axis

2019 · Qiulun Lu, Zejun Ma, et al. · Nature Communications · 134

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo

2019 · Shengnan Wu, Qiulun Lu, et al. · Circulation · 298

Mitochondria-associated endoplasmic reticulum membranes in the heart

2018 · Shengnan Wu, Ming-Hui Zou · Archives of Biochemistry and Biophysics · 32

β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4

2018 · Young-min Han, Tatiana Bedarida, et al. · Molecular Cell · 149

Obesity Paradox and Smoking Gun

2018 · Xi-Yong Yu, Ping Song, et al. · Circulation Research · 28

Measurement of Reactive Oxygen Species (ROS) and Mitochondrial ROS in AMPK Knockout Mice Blood Vessels

2018 · Qilong Wang, Ming-Hui Zou · Methods in molecular biology · 125

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

2017 · Bei Wang, Jiali Nie, et al. · Circulation Research · 334

SNRK (Sucrose Nonfermenting 1-Related Kinase) Promotes Angiogenesis In Vivo

2017 · Qiulun Lu, Zhonglin Xie, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 33

AMP-Activated Protein Kinase γ2 to the Rescue in Ischemic Heart

2017 · Ye Ding, Ming-Hui Zou · Circulation Research · 2

Tryptophan-Derived 3-Hydroxyanthranilic Acid Contributes to Angiotensin II–Induced Abdominal Aortic Aneurysm Formation in Mice In Vivo

2017 · Qiongxin Wang, Ye Ding, et al. · Circulation · 86