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Effect of Low Dose Methotrexate on Arterial Inflammation in HIV

Description: PUBLIC HEALTH RELEVANCE: HIV-infected individuals on effective antiretroviral therapy are at increased cardiovascular disease (CVD) risk because of persistent inflammation. This study will test the hypothesis that inflammation drives CVD risk in HIV infection by evaluating the effects of reducing inflammation using low-dose methotrexate on arterial inflammation and immune activation in treated HIV-infected individuals. (End of abstract)
Funding type: research
Funder scheme: R01
Start date: 2014-08-15
End date: 2019-05-31
Investigator: AHMED A TAWAKOL
Institution: MASSACHUSETTS GENERAL HOSPITAL
Field: Medicine
Funded outputs count: 21
Funder award ID: R01HL122177
OpenAlex ID: G7994547111
The effect of low-dose methotrexate on arterial inflammation in persons living with human immunodeficiency virus: A double-blind randomized placebo-controlled pilot trial
2025 · Ahmed Tawakol, Heather Ribaudo, et al. · Journal of Nuclear Cardiology · 1
Association of Socioeconomic Status and Infarct Volume With Functional Outcome in Patients With Ischemic Stroke
2022 · Ahmed Ghoneem, Michael T. Osborne, et al. · JAMA Network Open · 45
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Inflammation of the periodontium associates with risk of future cardiovascular events
2021 · Thomas E. Van Dyke, Karim El Kholy, et al. · Journal of Periodontology · 74
A leucopoietic-arterial axis underlying the link between ambient air pollution and cardiovascular disease in humans
2020 · Shady Abohashem, Michael T Osborne, et al. · European Heart Journal · 67
Periodontal Disease Associates With Arterial Inflammation Via Potentiation of a Hematopoietic-Arterial Axis
2019 · Amorina Ishai, Michael T. Osborne, et al. · JACC. Cardiovascular imaging · 34
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Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease
2019 · Ahmed Tawakol, Michael T. Osborne, et al. · Journal of the American College of Cardiology · 182
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Amygdalar Metabolic Activity Independently Associates With Progression of Visceral Adiposity
2018 · Amorina Ishai, Michael T Osborne, et al. · The Journal of Clinical Endocrinology & Metabolism · 25
Advances in coronary molecular imaging: Leveraging the power of image processing
2018 · Amr Abdelbaky, Georges El Fakhri, et al. · Journal of Nuclear Cardiology
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Amygdalar activity predicts future incident diabetes independently of adiposity
2018 · Michael T. Osborne, Amorina Ishai, et al. · Psychoneuroendocrinology · 41
Metabolic and Molecular Imaging of Atherosclerosis and Venous Thromboembolism
2017 · Eric A. Osborn, Chase W. Kessinger, et al. · Journal of Nuclear Medicine · 31
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Molecular Imaging of Atheroma
2017 · Ahmed Tawakol, Michael T. Osborne, et al. · Circulation Cardiovascular Imaging · 5
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Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study
2017 · Ahmed Tawakol, Amorina Ishai, et al. · The Lancet · 638
Molecular Imaging of Atherosclerosis: a Clinical Focus
2017 · Mohammed M. Chowdhury, Ahmed Tawakol, et al. · Current Cardiovascular Imaging Reports · 11
Association of Arterial and Lymph Node Inflammation With Distinct Inflammatory Pathways in Human Immunodeficiency Virus Infection
2016 · Ahmed Tawakol, Amorina Ishai, et al. · JAMA Cardiology · 62
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Effects of Antiretroviral Therapy on Immune Function and Arterial Inflammation in Treatment-Naive Patients With Human Immunodeficiency Virus Infection
2016 · Markella V. Zanni, Mabel Toribio, et al. · JAMA Cardiology · 83
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GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo
2016 · Parmanand Singh, Silvia González-Ramos, et al. · Journal of Nuclear Medicine · 27
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Relationship Between Measures of Adiposity, Arterial Inflammation, and Subsequent Cardiovascular Events
2016 · Amparo L. Figueroa, Richard A.P. Takx, et al. · Circulation Cardiovascular Imaging · 70
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Increased arterial inflammation in individuals with stage 3 chronic kidney disease
2015 · Richard A. P. Takx, Megan H. MacNabb, et al. · European Journal of Nuclear Medicine and Molecular Imaging · 19
Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation
2015 · Philip Joseph, Amorina Ishai, et al. · International journal of cardiac imaging · 16
HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages
2015 · Ahmed Tawakol, Parmanand Singh, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 194
1.モンテカルロ法による撮影時のスペクトルのシュミレーション : 撮影i : 中部部会
1987 · 孝治 黒川, 孝広 高田, et al. · 日本放射線技術學會雜誌
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