Epigenetic changes in synaptic and inflammatory genes involved in the age-dependent development of Alzheimer's disease pathologies andcognitive decline
Description: Project Narrative Histone modifications and DNA methylation are epigenetic factors that may mediate the influence of environmental factors on AD-related gene expression. The long-term goal of this research project is to uncover the epigenetic and molecular mechanisms underlying the development of AD and of healthy aging. The immediate goal is to discover differences in the epigenetic silencing of synaptic and neuroinflammatory genes that predict AD pathology and cognitive impairment and that may serve as biomarkers and targets for therapy.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2016-09-15
End date: 2021-08-31
Investigator: RHODA AU
Institution: BOSTON UNIVERSITY MEDICAL CAMPUS
Funded outputs count: 94
Funder award ID: RF1AG054156
OpenAlex ID: G7995509103