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Investigation of pathogenic mechanisms for central post-stroke pain and its accompanying emotional disorder - evaluation of microglial activation hypothesis

Description: In this study, we have established experimental conditions that enabled us to measure both stable mechanical withdrawal thresholds of hindpaws and emotional behaviors of thalamic hemorrhage-induced central post-stroke pain model mice. We found that systemic administration of inhibitors for microglial activation including minocycline and p38 MAP kinase inhibitors significantly alleviated the expression of both thalamic hemorrhage-induced mechanical allodynia and increased locomotor activity. Furthermore, N-type voltage-gated Ca channels were suggested to contribute to the development of the thalamic hemorrhage-induced mechanical allodynia in the acute phase. In contrast, we have not yet detected significant thalamic hemorrhage-induced depression-like behaviors in both acute and subacute phases. Thus, further study is necessary for the detection of the depression-like behaviors.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,810,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2015-04-01

End date: 2018-03-31

Investigator: Kazunori ARITA (lead)

Institution: Kagoshima University

Topic: Pain Mechanisms and Treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences