Screening for modulators of Tat positive feedback for biasing HIV latency
Description: PUBLIC HEALTH RELEVANCE: In biological systems, coupled regulatory mechanisms often control the dynamics of fate decisions and their resulting phenotype. In HIV-1 transcriptional feedback these mechanisms contribute fluctuations in gene expression, or `noise' causing diverse levels in gene products and phenotypic diversity. This project aims to exploit noise analysis and drug screening to identify feedback modulators to bias viral decision-making.
Funding type: career_development
Funder scheme: K22
Start date: 2015-08-07
End date: 2017-07-31
Investigator: ROY DAVID DAR
Institution: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
Funded outputs count: 11
Funder award ID: K22AI120746
OpenAlex ID: G7996723219